Exercise Fatiguability in Older Adults: The Protective Effects of Dietary Nitrate Supplementation

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-05-01

Study Completion Date

2023-12-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Vascular and skeletal muscle function decline with age and are associated with decreased nitric oxide (NO) bioavailability. Dietary nitrate supplementation in the form of beet root juice increases NO bioavailability and improves exercise tolerance in younger adults, yet its effects on fatigability in older adults are largely unknown. The proposed research will investigate the impact of increased NO bioavailability on vascular function, skeletal muscle bioenergetics, and fatigability in older (≥65 yrs) men and women.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Nitrate and Exercise Performance in Middle to Older Aged Adults

NCT03371966

Aging

COMPLETED NA

Beetroot Juice Resistance Training Older Adults

NCT05460351

Sarcopenia Old Age; Atrophy

COMPLETED NA

Effects of Drinking Beetroot Juice on Exercise Performance in Patients With Fibrotic Interstitial Lung Disease

NCT04299945

Interstitial Lung Disease

RECRUITING NA

The Effect of Beetroot Juice Supplementation Dose on Neuromuscular Performance During Resistance Exercise

NCT05957835

High Nitrate Dose Moderate Nitrate Dose Low Nitrate Dose +1 more

UNKNOWN NA

Beetroot Juice Effects on Contractile or Neuromuscular Properties in Male Trained Sprinters

NCT06675682

Nitrates Placebo

COMPLETED NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Aging

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Beetroot Juice

The subject will ingest 140mL of a nitrate-rich beetroot juice each day for 7 consecutive days.

Group Type ACTIVE_COMPARATOR

Beetroot Juice

Intervention Type DIETARY_SUPPLEMENT

7 days of 140 mL per day of beetroot juice

Placebo Beetroot Juice

The subject will ingest 140mL of a placebo (nitrate-depleted) beetroot juice each day for 7 consecutive days.

Group Type PLACEBO_COMPARATOR

Placebo Beetroot Juice

Intervention Type OTHER

7 days of 140 mL per day of placebo beetroot juice

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Beetroot Juice

7 days of 140 mL per day of beetroot juice

Intervention Type DIETARY_SUPPLEMENT

Placebo Beetroot Juice

7 days of 140 mL per day of placebo beetroot juice

Intervention Type OTHER

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

James White Drinks Beet It Sport 400

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Healthy men and women ≥ 60 years old

Exclusion Criteria

1. body mass index ≥40 kg/m2;
2. type 1 or type 2 diabetes or HbA1c \>6.5%
3. uncontrolled hypertension;
4. active cancer, cancer in remission, or having received treatment for any form of cancer in the previous five years;
5. coronary artery disease;
6. cardiovascular disease (e.g., PAD, PVD);
7. abnormal and untreated thyroid function;
8. chronic and/or regular nonsteroidal anti-inflammatory drugs (NSAID) consumption,
9. tobacco use (includes smoking);
10. any condition that presents a limitation to exercise (e.g., severe arthritis, COPD, neuromuscular disorder, moderate or severe cognitive impairment, Alzheimer's Disease, severe untreated sleep apnea).

Minimum Eligible Age

60 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes