Effect of Beet-root Juice and PBM Treatments on Muscle Fatigue

NCT ID: NCT05596474

Last Updated: 2024-03-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

10 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-09-09

Study Completion Date

2024-08-31

Brief Summary

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The goal of this randomized counterbalanced repeated measures study is to test beet-root juice supplementation and red light therapy augment forearm muscle endurance in apparently healthy older adults over 65 years of age. The main questions seek to answer the following question:

Does beet-root juice supplementation improve forearm muscle endurance compared to a placebo supplement?

Does red light therapy improve forearm muscle endurance compared to a sham light exposure?

Does beet-root juice supplementation in combination with red light therapy improve forearm muscle endurance compared to a placebo-sham light control?

Detailed Description

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Conditions

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Health Care Utilization Healthy Aging

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Participants

Study Groups

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Beet-root juice plus red-light therapy

Group Type EXPERIMENTAL

Beet-root juice

Intervention Type DIETARY_SUPPLEMENT

Two days prior to the forearm endurance protocol, participants will be provided and instructed to consume a 400mg nitrate once per day. On the day of the forearm endurance protocol, the participants will be provided and instructed to consume a third 400mg dose of nitrates at least 150 minutes before forearm endurance testing.

red-light therapy

Intervention Type RADIATION

Participants will place their dominant forearm 15 centimeters away from the light source and have their dominant forearm exposed to 660nm wave length light for 10-minutes.

Beet-root juice plus sham light therapy

Group Type SHAM_COMPARATOR

Beet-root juice

Intervention Type DIETARY_SUPPLEMENT

Two days prior to the forearm endurance protocol, participants will be provided and instructed to consume a 400mg nitrate once per day. On the day of the forearm endurance protocol, the participants will be provided and instructed to consume a third 400mg dose of nitrates at least 150 minutes before forearm endurance testing.

sham light

Intervention Type RADIATION

Participants will place their dominant forearm 15 centimeters away from the light source and have their dominant forearm exposed to sham light for 10-minutes.

Placebo plus red-light therapy

Group Type PLACEBO_COMPARATOR

red-light therapy

Intervention Type RADIATION

Participants will place their dominant forearm 15 centimeters away from the light source and have their dominant forearm exposed to 660nm wave length light for 10-minutes.

Placebo

Intervention Type DIETARY_SUPPLEMENT

Two days prior to the forearm endurance protocol, participants will be provided and instructed to consume a nitrate depleted placebo once per day. On the day of the forearm endurance protocol, the participants will be provided and instructed to consume a third dose of the nitrate depleted placebo at least 150 minutes before forearm endurance testing.

Placebo plus sham light therapy

Group Type ACTIVE_COMPARATOR

Placebo

Intervention Type DIETARY_SUPPLEMENT

Two days prior to the forearm endurance protocol, participants will be provided and instructed to consume a nitrate depleted placebo once per day. On the day of the forearm endurance protocol, the participants will be provided and instructed to consume a third dose of the nitrate depleted placebo at least 150 minutes before forearm endurance testing.

sham light

Intervention Type RADIATION

Participants will place their dominant forearm 15 centimeters away from the light source and have their dominant forearm exposed to sham light for 10-minutes.

Interventions

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Beet-root juice

Two days prior to the forearm endurance protocol, participants will be provided and instructed to consume a 400mg nitrate once per day. On the day of the forearm endurance protocol, the participants will be provided and instructed to consume a third 400mg dose of nitrates at least 150 minutes before forearm endurance testing.

Intervention Type DIETARY_SUPPLEMENT

red-light therapy

Participants will place their dominant forearm 15 centimeters away from the light source and have their dominant forearm exposed to 660nm wave length light for 10-minutes.

Intervention Type RADIATION

Placebo

Two days prior to the forearm endurance protocol, participants will be provided and instructed to consume a nitrate depleted placebo once per day. On the day of the forearm endurance protocol, the participants will be provided and instructed to consume a third dose of the nitrate depleted placebo at least 150 minutes before forearm endurance testing.

Intervention Type DIETARY_SUPPLEMENT

sham light

Participants will place their dominant forearm 15 centimeters away from the light source and have their dominant forearm exposed to sham light for 10-minutes.

Intervention Type RADIATION

Other Intervention Names

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Beet it Sport MitoMIN

Eligibility Criteria

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Inclusion Criteria

* Self-reports performing at least 30 minutes of light to moderate intensity physical activity 3 times per week for the last three months

Exclusion Criteria

* Currently smoke
* Have smoked within the last 6 months
* Are taking taking supplements known to increase blood nitrate levels
* Have a known kidney disease
* Have a known liver disease
* Have a known thyroid condition
* Have a known gastritis condition
* Are taking medications that are known to cause complications with nitrate supplementation
* Have known or reported joint pain within the dominant hand
Minimum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Wake Forest University

OTHER

Sponsor Role lead

Responsible Party

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Andrew Wells, Ph.D

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Andrew D Wells, Ph.D.

Role: PRINCIPAL_INVESTIGATOR

Wake Forest University, Reynolda Campus

Locations

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Wake Forest Univesity

Winston-Salem, North Carolina, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Andrew D Wells, Ph.D.

Role: CONTACT

(336) 758-5837 ext. 2156

Facility Contacts

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Andrew D Wells, Ph.D.

Role: primary

336-758-5837 ext. 2156

Other Identifiers

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IRB00024675

Identifier Type: -

Identifier Source: org_study_id

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