Effects of a Pre-Workout Dietary Supplement on Training Adaptations

NCT ID: NCT02999581

Last Updated: 2016-12-21

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 122 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2014-03-31
• Study Completion Date: 2014-12-31

Brief Summary

The purpose of this study is to examine the effects of a pre-workout dietary supplement during resistance training on training adaptations.

Detailed Description

A number of nutritional strategies have been developed to optimize nutrient delivery prior to exercise. This includes providing carbohydrate and a number of ergogenic nutrients prior to, during and/or following exercise. As a result, a number of pre-workout supplements have been developed to increase energy availability, promote vasodilation and/or positively affect exercise capacity. The purpose of this study is to investigate the effects of ingesting a pre-workout dietary supplement during resistance training on training adaptations.

Conditions

Dietary Modification

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: HEALTH_SERVICES_RESEARCH
• Blinding Strategy: DOUBLE

Study Groups

C4 Extreme

One dose of 12 grams (powder mixed with water): 1500 mg beta alanine, 1000 mg creatine nitrate, 1000 mg arginine alpha-ketoglutarate, 250 mg vitamin C, 150 mg N-Acetyl-Tyrosine, 135 mg caffeine, 7.5 mg L-Dopa, 30 mg vitamin B3, 10 mg Bitter Orange (Citrus Aurantium) fruit standardized for 30% synephrine (Advantra Z), 0.5 mg vitamin B6, 0.25 mg vitamin B9, and 0.035 mg vitamin B12.

Group Type: EXPERIMENTAL

C4 Extreme, C4 Extreme (without Advantra Z)

Intervention Type: DIETARY_SUPPLEMENT

C4 Extreme (without Advantra Z)

One dose of 12 grams (powder mixed with water): 1500 mg beta alanine, 1000 mg creatine nitrate, 1000 mg arginine alpha-ketoglutarate, 250 mg vitamin C, 150 mg N-Acetyl-Tyrosine, 135 mg caffeine, 7.5 mg L-Dopa, 30 mg vitamin B3, 0.5 mg vitamin B6, 0.25 mg vitamin B9, and 0.035 mg vitamin B12.

Group Type: ACTIVE_COMPARATOR

C4 Extreme, C4 Extreme (without Advantra Z)

Intervention Type: DIETARY_SUPPLEMENT

Placebo

One dose of flavored placebo (powder mixed with water)

Group Type: PLACEBO_COMPARATOR

C4 Extreme, C4 Extreme (without Advantra Z)

Intervention Type: DIETARY_SUPPLEMENT

Interventions

C4 Extreme, C4 Extreme (without Advantra Z)

Intervention Type: DIETARY_SUPPLEMENT

Eligibility Criteria

Inclusion Criteria

• you are an apparently healthy and recreationally active male between the ages of 18 and 40.
• you will need to have at least six months immediate prior history of resistance training on the bench press and leg press or squat.

Exclusion Criteria

• you have a history of treatment for metabolic disease (i.e., diabetes), hypertension, hypotension, thyroid disease, arrhythmia and/or cardiovascular disease;
• you are currently using prescription medications;
• you have an intolerance to caffeine and/or other natural stimulants;
• you have a history of smoking;
• you drink excessively (i.e., 12 drinks per week or more);

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 40 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: Yes

Sponsors

Nutrabolt

INDUSTRY

Sponsor Role: collaborator

Texas A&M University

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

References

Jung YP, Earnest CP, Koozehchian M, Cho M, Barringer N, Walker D, Rasmussen C, Greenwood M, Murano PS, Kreider RB. Effects of ingesting a pre-workout dietary supplement with and without synephrine for 8 weeks on training adaptations in resistance-trained males. J Int Soc Sports Nutr. 2017 Jan 3;14:1. doi: 10.1186/s12970-016-0158-3. eCollection 2017.

Reference Type: DERIVED

PMID: 28096757 (View on PubMed)

Other Identifiers

IRB2014-0079FX

Identifier Type: -

Identifier Source: org_study_id