Nutrient Supplementation Influences Mitochondria Adaptation

NCT ID: NCT03561337

Last Updated: 2020-05-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

24 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-10-01

Study Completion Date

2014-06-01

Brief Summary

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Twenty-four well trained runners (VO2max 60.73.7 ml O2 Kg-1 min1) completed a six week block randomized controlled intervention period. Subjects were randomly assigned to either PRO-CHO or CHO and matched in pairs for gender, age, VO2max, training and performance status. The PRO- CHO group ingested a protein beverage (0.3g kg-1) before and protein-carbohydrate beverage (0.3g protein kg-1 and 0.1g carbohydrate kg-1) after each exercise session. The CHO group ingested energy matched carbohydrate. Post-absorptive muscle biopsies were obtained pre and post intervention for analysis HAD, CS and PGC-1. Subjects completed two physical tests 6 km performance test (pre, week 1 and week 6) and aVo2max test (pre and post intervention).

Detailed Description

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Conditions

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Performance Nutrition Protein

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

block randomized controlled intervention
Primary Study Purpose

OTHER

Blinding Strategy

SINGLE

Participants
Single blinded

Study Groups

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PROTEIN-CARBOHYDRATE

Intervention group receiving protein and carbohydrate supplement

Group Type EXPERIMENTAL

PROTEIN-CARBOHYDRATE

Intervention Type DIETARY_SUPPLEMENT

PRO before and PRO-CHO after training

CARBOHYDRATE

Intervention groups receiving carbohydrate supplement

Group Type PLACEBO_COMPARATOR

CARBOHDYRATE

Intervention Type DIETARY_SUPPLEMENT

CHO before and after training

Interventions

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PROTEIN-CARBOHYDRATE

PRO before and PRO-CHO after training

Intervention Type DIETARY_SUPPLEMENT

CARBOHDYRATE

CHO before and after training

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

1. maximal oxygen uptake (VO2max) of \>50ml O2 kg-1 min-1 for women and \>55ml O2 kg-1 min-1 for men,
2. running at least 3 times a week and
3. running being the primarily training form

Exclusion Criteria

1. use of medicine
2. diagnosed metabolic diseases
3. injuries which hindered running and body mass index (BMI) \< 25 kg m-2
Minimum Eligible Age

18 Years

Maximum Eligible Age

55 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Aarhus

OTHER

Sponsor Role lead

Responsible Party

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Mette Hansen

Principal investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Aarhus University, Department for Public Health, Section for Sport Science

Aarhus, , Denmark

Site Status

Sport Science, Department of Public Health, Aarhus University

Aarhus, , Denmark

Site Status

Countries

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Denmark

References

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Hansen M, Oxfeldt M, Larsen AE, Thomsen LS, Rokkedal-Lausch T, Christensen B, Rittig N, De Paoli FV, Bangsbo J, Ortenblad N, Madsen K. Supplement with whey protein hydrolysate in contrast to carbohydrate supports mitochondrial adaptations in trained runners. J Int Soc Sports Nutr. 2020 Sep 7;17(1):46. doi: 10.1186/s12970-020-00376-3.

Reference Type DERIVED
PMID: 32894140 (View on PubMed)

Other Identifiers

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AURunners2017

Identifier Type: -

Identifier Source: org_study_id

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