The Impact of a Caffeinated Sports Drink on Performance

NCT ID: NCT06721793

Last Updated: 2026-01-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

26 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-12-12

Study Completion Date

2025-12-16

Brief Summary

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Caffeine is known to enhance physical and mental performance, but few beverages combine caffeine with electrolytes and carbohydrates to enhance exercise performance. This study evaluates a caffeinated electrolyte-glucose drink's effect on endurance, strength, and cognition. Using a repeated-measures, cross-over design, 20 trained cyclists will complete one familiarization and four randomized 3-hour experimental trials (Liquid I.V.™ Energy Multiplier, Hydration Multiplier, Sugar-Free Hydration Multiplier, and water). Each trial includes 2 hours of cycling in a warm environment (32ºC), followed by strength and cognitive assessments. Cycling performance, capillary blood, urine, and expiratory gases will be collected.

Detailed Description

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Each subject will complete 5 trials (1 familiarization and 4 experimental) consisting of approximately 2 hours cycling in a warm environment (90ºF), followed by strength assessment and cognitive assessment via questionnaire. Each trial will be identical, with the only difference being the type of drink consumed during each trial. The first trial will be for familiarization without any blood sampling. The rest of the trials will be completed in a randomized order and the drink consumed

Cycling Endurance Exercise Performance

The exercise test will consist of a series of three consecutive cycling sets in a warm environment (90ºF), with each series consisting of:

1. a 30-min submaximal ride (50% maximal power as determined from the initial)
2. a 5-km time trial race-like performance effort. During each 30 min submaximal rides participants will drink a total 500 mL of fluid spread out during the 30 min. During the 5 km performance test the participants will drink 25 mL of fluid at the end of each kilometer.

At regular intervals throughout the exercise task, body weight, blood samples, respiratory gasses, and perceptual data will be collected. See study schematic provided below for specific measurement timepoints.

Upon completion of the cycling task subjects will moved to another room with cool temperature (70ºF), where strength and cognitive function will be assessed to determine the influence of each beverage on indices of exercise performance and fatigue.

Conditions

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Dehydration Dehydration Related to Exercise

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Counter balanced cross-over design trial with 4 arms differing only on the type of drink consumed during exercise.

Each trial includes 2 hours of cycling in a warm environment (32ºC), followed by strength and cognitive assessments.
Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Participants
The type of drink ingested by the subjects will be labeled with a letter in a generic water bottle. During the trial with water a non-caloric, non-sodium-containing sweetener will be used.

Study Groups

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Water

Water masked with non-caloric and no-sodium

Group Type PLACEBO_COMPARATOR

Water (Placebo)

Intervention Type DIETARY_SUPPLEMENT

flavored water with non-caloric, non-sodium-containing sweetner

Carbohydrate electrolyte solution

2% carbohydrate solution with 1,020 mg/L of Sodium

Group Type EXPERIMENTAL

carbohydrate electrolyte drink

Intervention Type DIETARY_SUPPLEMENT

2% carbohydrate solution with 1,020 mg/L of Sodium

no-sugar electrolyte solution

1% carbohydrate solution with 1,060 mg/L of Sodium

Group Type EXPERIMENTAL

no-sugar electrolyte drink

Intervention Type DIETARY_SUPPLEMENT

1% carbohydrate solution with 1,060 mg/L of Sodium

Caffeinated carbohydrate electrolyte solution

1% carbohydrate solution with 1,000 mg/L of Sodium, and 200mg/L Caffeine

Group Type EXPERIMENTAL

Caffeinated Carbohydrate and electrolyte drink

Intervention Type DIETARY_SUPPLEMENT

2% carbohydrate solution with 1,000 mg/L of Sodium, and 200mg/L caffeine

Interventions

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carbohydrate electrolyte drink

2% carbohydrate solution with 1,020 mg/L of Sodium

Intervention Type DIETARY_SUPPLEMENT

no-sugar electrolyte drink

1% carbohydrate solution with 1,060 mg/L of Sodium

Intervention Type DIETARY_SUPPLEMENT

Caffeinated Carbohydrate and electrolyte drink

2% carbohydrate solution with 1,000 mg/L of Sodium, and 200mg/L caffeine

Intervention Type DIETARY_SUPPLEMENT

Water (Placebo)

flavored water with non-caloric, non-sodium-containing sweetner

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* Age 18-55
* Healthy and injury-free (muscle, skeletal) for greater than 2 months
* Active cyclists who train at least 3 times per week
* Body mass index (BMI) range of 18.5-30 kg/m2

Exclusion Criteria

* • History of caffeine sensitivity

* Cancer Diagnosis during the last 5 years
* Pregnancy
* History of renal disease, hypertension
* History of a heat stroke
* Use of testosterone therapy
* Adults who are unable to consent (impaired decision-making capacity)
Minimum Eligible Age

18 Years

Maximum Eligible Age

55 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Arizona State University

OTHER

Sponsor Role lead

Responsible Party

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Stavros Kavouras

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Stavros Kavouras, PhD

Role: PRINCIPAL_INVESTIGATOR

Arizona State University

Locations

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Arizona State University - Hydration Science Lab

Phoenix, Arizona, United States

Site Status

Countries

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United States

Other Identifiers

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AWD00039989

Identifier Type: OTHER

Identifier Source: secondary_id

FP00041543

Identifier Type: -

Identifier Source: org_study_id

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