Effects of Herbal Supplements on Endurance Exercise Performance

NCT ID: NCT03929575

Last Updated: 2021-01-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

13 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-05-01

Study Completion Date

2019-12-01

Brief Summary

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Cordyceps and Rhodiola are two common herbal supplements marketed and consumed as adaptogens to athletes with regard to enhanced performance. The effects of these supplements has been well studied in animals but whether or not the same effects translate to humans is still unclear. Thus, the primary purpose of this study is to determine whether combined supplementation of Rhodiola and Cordyceps, compared to Rhodiola alone and placebo, will demonstrate a greater improvement in oxygen consumption (ie. VO2 max).

Detailed Description

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Herbal supplements are consumed worldwide with surveys approximating five billion dollars spent annually by consumers in the United States alone. Herbal supplements, such as Rhodiola and Cordyceps, both of which are considered to be adaptogens, remain popular among athletes. These adaptogens act as antioxidants, which have been speculated to confer endurance performance benefits by delaying muscle fatigue via the attenuation of muscle damage accumulation and its related by-products during prolonged or exhaustive exercise. Nevertheless, previous research investigating the individual effects of Rhodiola and Cordyceps on aerobic training performance remain equivocal. Moreover, literature elucidating the potential additive effects of Rhodiola and Cordyceps in human subjects are scarce. Therefore, the purpose of the present study is to determine the acute, additive influence of oral Rhodiola and Cordyceps supplementation on VO2 max, with secondary variables of interest being plasma glucose and lactate concentration, and measures of gastrointestinal distress.

Conditions

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Exercise Performance

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Blocked-randomized, crossover design
Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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Placebo of calcium

Participants will consume 250 mg of calcium

Group Type PLACEBO_COMPARATOR

Placebo of calcium

Intervention Type DIETARY_SUPPLEMENT

Ingestion of 250 mg of calcium

Rhodiola

Participants will consume 250 mg of Rhodiola

Group Type EXPERIMENTAL

Rhodiola

Intervention Type DIETARY_SUPPLEMENT

Ingestion of 250 mg of Rhodiola

Rhodiola and Cordyceps

Participants will consume a combination of 250 mg of Rhodiola and 225 mg of Cordyceps

Group Type EXPERIMENTAL

Rhodiola and Cordyceps

Intervention Type DIETARY_SUPPLEMENT

Ingestion of 250 mg of Rhodiola and 225 mg of Cordyceps

Interventions

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Rhodiola and Cordyceps

Ingestion of 250 mg of Rhodiola and 225 mg of Cordyceps

Intervention Type DIETARY_SUPPLEMENT

Placebo of calcium

Ingestion of 250 mg of calcium

Intervention Type DIETARY_SUPPLEMENT

Rhodiola

Ingestion of 250 mg of Rhodiola

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* Body Mass Index between 18.5 and 35 kg/m\^2
* Non-smoking (assessed by Health History Questionnaire)
* English-speaking
* Regular participation in physical activity (\>4 hours per week)

Exclusion Criteria

* Medical conditions that prohibit physical activity (assessed by Health History Questionnaire)
* Pregnant women or women expecting/trying to become pregnant
* BMI greater than or equal to 35 kg/m\^2
* Current smoker (assessed by Health History Questionnaire)
Minimum Eligible Age

18 Years

Maximum Eligible Age

30 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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California Polytechnic State University-San Luis Obispo

OTHER

Sponsor Role lead

Responsible Party

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Todd Hagobian

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Todd Hagobian, PhD

Role: PRINCIPAL_INVESTIGATOR

California Polytechnic State University-San Luis Obispo

Locations

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California Polytechnic State University

San Luis Obispo, California, United States

Site Status

Countries

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United States

Other Identifiers

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CPKINE454

Identifier Type: -

Identifier Source: org_study_id

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