Ketone Supplementation and Exercise Performance

NCT ID: NCT03954665

Last Updated: 2019-07-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-09-30

Study Completion Date

2020-03-31

Brief Summary

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The purpose of this study is to observe the effects of exogenous ketone supplements during shorter bouts of exercise testing on twenty collegiate endurance trained athletes (18-25 years of age).

Detailed Description

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Some believe very high fat diets (\>70% energy) can enhance exercise performance by providing additional fuel (ketones) for energy metabolism, at least for very prolonged exercise (\>3-4h). Regardless, this diet is difficult to maintain so it has been suggested that ingesting ketone salts along with a normal carbohydrate (CHO) diet might be more practical. The purpose of this study is to observe the effects of ketone salt ingestion on shorter term (up to \~15 min) exercise performance. Endurance trained (≥2 year training experience; ≥7 h/week) collegiate athletes (n=20) of similar body mass (♀; 55-60kg; ♂; 75-80kg) and age 18-25y) consuming 5-6g CHO•kg-1•d-1) will be tested before and after 1 and 7d of ketone salt (Prüvit, Carrollton TX, US) supplementation (0.6-0.8g•kg-1•d-1). Participants will perform two exercise performance tests (a 10km cycle time trial and a 30s Wingate cycle test on separate days) before and after supplementation. Blood samples (glucose, lactic acid, and ketone concentration) will be taken at: baseline and following each performance test. It is hypothesized that ketone salt supplementation will increase blood ketone concentration but will not enhance these exercise performance tests.

Conditions

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Ketosis Exercise Performance Ketoses, Metabolic

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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Baseline Testing

Baseline testing for a 10km cycle time trial and a 30s Wingate cycle test.

Group Type ACTIVE_COMPARATOR

Baseline 10 km time trial

Intervention Type BEHAVIORAL

A baseline 10 km Cycling time trial test will be conducted

Baseline 30s Wingate

Intervention Type BEHAVIORAL

A baseline 30s all-out test to measure peak power output

Dietary Supplement: Exogenous Ketone Salt

Ketone salt supplementation (0.6-0.8g•kg-1•d-1) 7-days. Participants will perform two exercise performance tests (a 10km cycle time trial and a 30s Wingate cycle test on separate days) after supplementation.

Group Type EXPERIMENTAL

10 km time trial

Intervention Type BEHAVIORAL

10 km Cycling time trial test will be conducted to examine the effects of the Exogenous Ketone Salts on time

30s Wingate

Intervention Type BEHAVIORAL

30s all-out test to measure peak power output

Ketone

Intervention Type DIETARY_SUPPLEMENT

Supplement containing exogenous ketone salts

Interventions

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10 km time trial

10 km Cycling time trial test will be conducted to examine the effects of the Exogenous Ketone Salts on time

Intervention Type BEHAVIORAL

30s Wingate

30s all-out test to measure peak power output

Intervention Type BEHAVIORAL

Ketone

Supplement containing exogenous ketone salts

Intervention Type DIETARY_SUPPLEMENT

Baseline 10 km time trial

A baseline 10 km Cycling time trial test will be conducted

Intervention Type BEHAVIORAL

Baseline 30s Wingate

A baseline 30s all-out test to measure peak power output

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Healthy male or female Collegiate Endurance Trained Athletes
* ≥2 year training experience; ≥7 h/week
* Ages 18-25

Exclusion Criteria

* Smoker
* Injury that will affect exercise performance
* Sedentary Behaviour
* Currently following a High Fat diet/Ketogenic diet
* Taking Beta Blockers or Hypertension Medication
* Has Respiratory, Cardiovascular and/or Neuromuscular disease that is not cleared for exercise by a physician.
Minimum Eligible Age

18 Years

Maximum Eligible Age

25 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Western University, Canada

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Peter WR Lemon, PhD

Role: PRINCIPAL_INVESTIGATOR

Western University

Locations

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Exercise Nutrition Laboratory, Western University

London, Ontario, Canada

Site Status

Countries

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Canada

Central Contacts

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Sydney EL Isbell, BSc

Role: CONTACT

5196612111

Manuel D Quinones, MSc

Role: CONTACT

5196612111

Facility Contacts

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Peter WR Lemon, PhD

Role: primary

5196612111 ext. 88139

References

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Waldman HS, Basham SA, Price FG, Smith JW, Chander H, Knight AC, Krings BM, McAllister MJ. Exogenous ketone salts do not improve cognitive responses after a high-intensity exercise protocol in healthy college-aged males. Appl Physiol Nutr Metab. 2018 Jul;43(7):711-717. doi: 10.1139/apnm-2017-0724. Epub 2018 Feb 16.

Reference Type BACKGROUND
PMID: 29451991 (View on PubMed)

O'Malley T, Myette-Cote E, Durrer C, Little JP. Nutritional ketone salts increase fat oxidation but impair high-intensity exercise performance in healthy adult males. Appl Physiol Nutr Metab. 2017 Oct;42(10):1031-1035. doi: 10.1139/apnm-2016-0641. Epub 2017 Jul 27.

Reference Type BACKGROUND
PMID: 28750585 (View on PubMed)

Volek JS, Noakes T, Phinney SD. Rethinking fat as a fuel for endurance exercise. Eur J Sport Sci. 2015;15(1):13-20. doi: 10.1080/17461391.2014.959564. Epub 2014 Oct 2.

Reference Type RESULT
PMID: 25275931 (View on PubMed)

Other Identifiers

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113761

Identifier Type: -

Identifier Source: org_study_id

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