Ketone Esters and Metabolism During Recovery from Endurance Exercise

NCT ID: NCT06846840

Last Updated: 2025-02-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

NA

Total Enrollment

18 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-11-01

Study Completion Date

2025-05-01

Brief Summary

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Infusion of beta-hydroxybutyrate can suppress endogenous glucose production, which may result in increased net liver glycogen storage. If ketone esters exert similar effects, then the increase in liver glycogen storage may have implication for recovery from exercise and subsequent exercise performance.

The aim of this study is to assess the effects of ketone esters ingested during recovery from exercise, on metabolism and subsequent exercise capacity.

Detailed Description

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Conditions

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Exercise Metabolism

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Participants

Study Groups

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PLACEBO

Energy matched placebo containing medium-chain triglycerides and bitter taste

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DIETARY_SUPPLEMENT

Medium chain triglycerides and bitter tastant (Bitrex)

KETONE

Beta-hydroxybutyrate monoester

Group Type EXPERIMENTAL

Ketone ester

Intervention Type DIETARY_SUPPLEMENT

0.29 g per kilogram body mass per hour of ketone monoester (R)-3-hydroxybutyrate (R)-3-hydroxybutyl

Interventions

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Ketone ester

0.29 g per kilogram body mass per hour of ketone monoester (R)-3-hydroxybutyrate (R)-3-hydroxybutyl

Intervention Type DIETARY_SUPPLEMENT

Placebo

Medium chain triglycerides and bitter tastant (Bitrex)

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* VO2max ≥ 45mL.kg-1.min-1
* Weekly aerobic training \> 3hours.
* 2years running experience.
* BMI \< 30kg/m2

Exclusion Criteria

* \<18yrs or \>60yrs of age
* Habitual smoker within last 5 years.
* History of uncontrollable metabolic or respiratory disease.
* Currently taking medication, following a low carbohydrate or ketogenic diet, or consuming nutritional ketone supplements.
* History of Irritable Bowel Syndrome
Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Bath

OTHER

Sponsor Role lead

Responsible Party

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Javier Gonzalez

Professor of Nutrition and Metabolism

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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University of Bath

Bath, Bath, United Kingdom

Site Status

Countries

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United Kingdom

Other Identifiers

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5202-6834

Identifier Type: -

Identifier Source: org_study_id

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