Acute Effect of Exogenous Ketosis on Sleep Architecture Following Strenuous Exercise
NCT ID: NCT05439720
Last Updated: 2022-06-30
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
PHASE2
11 participants
INTERVENTIONAL
2022-05-15
2022-08-15
Brief Summary
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Before bedtime, a venous blood sample is taken to evaluate hormones playing an important role in sleep regulation. During the experimental sessions, the subjects sleep in a sleep facility to evaluate quality of sleep. Time spent in different sleep phases is measured via polysomnography (PSG). Urine output throughout the day and night will be collected for measurement of urinary excretion of adrenaline and noradrenaline as an index of intrinsic sympathetic activity.
Detailed Description
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Conditions
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Keywords
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
DOUBLE
Study Groups
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Exercise and ketone
Ketone ester is provided
Ketone ester
A dose of 25g of ketone ester after each training session and 30 minutes before sleeptime. The total dose is 75g of ketone ester.
Exercise
A 120 minutes cycling endurance training session (ET) two hours after breakfast and an evening high-intensity-interval training (HIIT) ending one hour before bedtime
Exercise and placebo
Placebo is provided
Placebo
Collagen peptan (3g) mixed with 1 mM bitter sucrose octaacetate and 20ml of pure water. A dose of 25g of placebo drink is provided after each training session and 30 minutes before sleeptime. The total dose is 75g of placebo drink.
Exercise
A 120 minutes cycling endurance training session (ET) two hours after breakfast and an evening high-intensity-interval training (HIIT) ending one hour before bedtime
Non-exercise and placebo
Placebo is provided
Placebo
Collagen peptan (3g) mixed with 1 mM bitter sucrose octaacetate and 20ml of pure water. A dose of 25g of placebo drink is provided after each training session and 30 minutes before sleeptime. The total dose is 75g of placebo drink.
Interventions
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Ketone ester
A dose of 25g of ketone ester after each training session and 30 minutes before sleeptime. The total dose is 75g of ketone ester.
Placebo
Collagen peptan (3g) mixed with 1 mM bitter sucrose octaacetate and 20ml of pure water. A dose of 25g of placebo drink is provided after each training session and 30 minutes before sleeptime. The total dose is 75g of placebo drink.
Exercise
A 120 minutes cycling endurance training session (ET) two hours after breakfast and an evening high-intensity-interval training (HIIT) ending one hour before bedtime
Eligibility Criteria
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Inclusion Criteria
* Recreational or competitive cyclists performing regularly cycling training sessions with an average training volume of more than 6 hours per week
* Good health status confirmed by a medical screening
* Body Mass Index (BMI) between 18 and 25
* Normal sleep pattern as assessed by the Pittsburgh Sleep Quality Index (PSQI)
* Moderate sleep chronotype, assessed by the Horne and Östberg questionnaire
Exclusion Criteria
* Depression or anxiety as assessed by the Beck Depression Inventory and Beck Anxiety Inventory
* Night-shifts or travel across time zones in the month preceding the study
* Any kind of injury/pathology that is a contra-indication to perform high-intensity exercise
* Intake of any medication or nutritional supplement that is known to affect exercise performance or sleep
* Smoking
* Involvement in elite athletic training at a semi-professional or professional level
* Current participation in another research trial
* Any other argument to believe that the subject is unlikely to successfully complete the full study protocol
18 Years
35 Years
MALE
Yes
Sponsors
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KU Leuven
OTHER
Responsible Party
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Peter Hespel
Principal Investigator
Locations
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Exercise Physiology Group
Leuven, , Belgium
Countries
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References
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Robberechts R, Albouy G, Hespel P, Poffe C. Exogenous Ketosis Improves Sleep Efficiency and Counteracts the Decline in REM Sleep after Strenuous Exercise. Med Sci Sports Exerc. 2023 Nov 1;55(11):2064-2074. doi: 10.1249/MSS.0000000000003231. Epub 2023 Jun 1.
Other Identifiers
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S65394
Identifier Type: -
Identifier Source: org_study_id