Effect of Exogenous Ketosis During Ultra-endurance Exercise
NCT ID: NCT05407753
Last Updated: 2022-06-07
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
PHASE2
24 participants
INTERVENTIONAL
2021-05-20
2022-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
BASIC_SCIENCE
DOUBLE
Study Groups
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Ketone ester
Subjects receive the ketone ester (R)-3-hydroxybutyl (R)-3-hydroxybutyrate (25g before ultrarun, 12.5g every 30 min during race, 25g immediately after race, 25g before sleep, 3 x 25g on day after race.
Ketone ester
Subjects receive the ketone ester at the following timepoints: 25g before ultrarun, 12.5g every 30 min during race, 25g immediately after race, 25g before sleep, 3 x 25g on day after race.
Con
Subjects receive a non-caloric, taste matched placebo (water and sucrose octaacetate).
Placebo
Subjects receive a non-caloric taste-matched placebo (water with sucrose octaacetate)
Interventions
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Ketone ester
Subjects receive the ketone ester at the following timepoints: 25g before ultrarun, 12.5g every 30 min during race, 25g immediately after race, 25g before sleep, 3 x 25g on day after race.
Placebo
Subjects receive a non-caloric taste-matched placebo (water with sucrose octaacetate)
Eligibility Criteria
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Inclusion Criteria
* Recreational or competitive runner having performed an ultramarathon (\>42km) during the last 2 years
* Good health status confirmed by a medical screening
* Body Mass Index (BMI) between 18 and 25
Exclusion Criteria
* Intake of any medication or nutritional supplement that is known to affect exercise performance
* Intake of analgesics, anti-inflammatory agents, or supplementary anti-oxidants, from 2 weeks prior to the start of the study.
* Blood donation within 3 months prior to the start of the study
* Smoking
* More than 3 alcoholic beverages per day
* Current participation in another research trial
* Any other argument to believe that the subject is unlikely to successfully complete the full study protocol
* Adherence to a high-fat, low-carbohydrate ketogenic diet (less than 20% of energy intake derived from carbohydrates)
18 Years
55 Years
MALE
Yes
Sponsors
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KU Leuven
OTHER
Responsible Party
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Peter Hespel
Principal Investigator
Locations
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Exercise Physiology Research Group
Leuven, Vlaams-Brabant, Belgium
Countries
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Other Identifiers
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S65311
Identifier Type: -
Identifier Source: org_study_id
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