Ketone Monoester Supplements, High Altitude, and Brain Blood Flow During Exercise
NCT ID: NCT07063732
Last Updated: 2025-07-14
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
14 participants
INTERVENTIONAL
2025-05-28
2025-08-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
DOUBLE
Study Groups
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High Altitude (3800m; Barcroft Research Station)
High altitude setting
Ketone Monoester (KME)
0.6 g KME per kg body mass; \[R\]-3-hydroxybutyl \[R\]-3-hydroxybutyrate. (Delta G Ketone, TΔS, Oxford).
Placebo
Inert, calorie-free placebo drink that is taste-matched to the ketone monoester supplement
Low Altitude (334m; University of Guelph)
Low altitude setting
Ketone Monoester (KME)
0.6 g KME per kg body mass; \[R\]-3-hydroxybutyl \[R\]-3-hydroxybutyrate. (Delta G Ketone, TΔS, Oxford).
Placebo
Inert, calorie-free placebo drink that is taste-matched to the ketone monoester supplement
Interventions
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Ketone Monoester (KME)
0.6 g KME per kg body mass; \[R\]-3-hydroxybutyl \[R\]-3-hydroxybutyrate. (Delta G Ketone, TΔS, Oxford).
Placebo
Inert, calorie-free placebo drink that is taste-matched to the ketone monoester supplement
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* No prescribed medications (oral contraceptives excluded)
* History of smoking
* Currently following a ketogenic diet or consuming exogenous ketogenic supplements
* History of heart, lung, blood vessel, or kidney disease
* Currently pregnant
18 Years
35 Years
ALL
Yes
Sponsors
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McMaster University
OTHER
Responsible Party
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Jeremy Walsh
Assistant Professor
Locations
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Barcroft Research Station
Bishop, California, United States
University of Guelph
Guelph, Ontario, Canada
Countries
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Facility Contacts
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References
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Gaskill SE, Ruby BC, Walker AJ, Sanchez OA, Serfass RC, Leon AS. Validity and reliability of combining three methods to determine ventilatory threshold. Med Sci Sports Exerc. 2001 Nov;33(11):1841-8. doi: 10.1097/00005768-200111000-00007.
Other Identifiers
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KETEX_WM
Identifier Type: -
Identifier Source: org_study_id
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