The Effects of Acute Ketone Monoester Supplementation on 20-Minute Time-Trial Performance in Trained Cyclists

NCT ID: NCT05226962

Last Updated: 2022-11-07

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 25 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2022-02-15
• Study Completion Date: 2022-10-01

Brief Summary

Diet can alter blood ketone levels and this in turn may affect exercise capacity. This study will determine if the acute ingestion of a ketone supplement alters cycling time trial performance. Participants will perform two trials in a randomized order. Each trial will involve a 20-minute bout of cycling on a stationary ergometer. Participants will ingest either a ketone supplement or a taste-matched placebo drink prior to exercise. Blood samples will be obtained to assess selected metabolic responses. This study will provide information regarding the effect of ketone supplementation on exercise responses.

Detailed Description

This study will determine if the acute ingestion of a ketone supplement alters cycling time trial performance. Trained participants with competitive cycling experience will be recruited. Exercise will involve a 20-minute bout of cycling on a stationary ergometer with the goal of producing the highest power output possible. Participants will ingest either a ketone supplement or a taste-matched placebo drink prior to exercise using a randomized, double-blind crossover design. Diet prior to exercise will be standardized between trials for a given participant. Blood samples will be obtained to assess selected metabolic responses. This study will provide information regarding the effect of ketone supplementation on exercise responses.

Conditions

Exercise; Ketosis

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: DOUBLE

Study Groups

Ketone

An acute bout of exercise performed after the ingestion of a commercial ketone monoester supplement.

Group Type: ACTIVE_COMPARATOR

Ketone monoester

Intervention Type: DIETARY_SUPPLEMENT

A commercial liquid supplement ingested in a dose intended to provide \~0.35 g of ketone monoester per kg body mass of the participant

Control

An acute bout of exercise performed after the ingestion of a taste-matched placebo supplement.

Group Type: PLACEBO_COMPARATOR

Placebo

Intervention Type: OTHER

A liquid placebo that is volume- and taste-matched to the ketone monoester supplement

Interventions

Ketone monoester

A commercial liquid supplement ingested in a dose intended to provide \~0.35 g of ketone monoester per kg body mass of the participant

Intervention Type: DIETARY_SUPPLEMENT

Placebo

A liquid placebo that is volume- and taste-matched to the ketone monoester supplement

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Habitually ingesting >50 g of dietary carbohydrate daily i.e. not following a ketogenic diet.
• Regularly performing cycling exercise at least 3 days per week and for a total of ≥5 hours per week.
• Having an estimated peak oxygen uptake of ≥55 ml/kg/min for males and ≥48 ml/kg/min for females based on the online fitness calculator available at: www.worldfitnesslevel.org.
• Having competitive cycling experience.

Exclusion Criteria

• Experiencing a condition that might preclude safe participation in physical activity and exercise, as determined by answering "Yes" to any question on Page 1 of the Canadian Society for Exercise Physiology Get Active Questionnaire.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 60 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

McMaster University

OTHER

Sponsor Role: lead

Responsible Party

Martin Gibala

Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Martin Gibala, PhD

Role: PRINCIPAL_INVESTIGATOR

McMaster University

Locations

McMaster University

Hamilton, Ontario, Canada

Countries

Canada

Other Identifiers

13837

Identifier Type: -

Identifier Source: org_study_id