The Effect of Acute Exogenous Oral Ketone Supplementation on Immune Cells Function and Immune Cells Histone Β-hydroxybutyrylation

NCT ID: NCT06590623

Last Updated: 2025-03-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

12 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-10-01

Study Completion Date

2025-06-01

Brief Summary

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To conduct a single-arm pilot study to determine how acute ingestion of an exogenous ketone monoester supplement alters the histone lysine β-hydroxybutyrylation and immune function in healthy human monocytes and lymphocytes.

Detailed Description

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Conditions

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Ketosis, Metabolic Immune Functions Histone Deacetylase (HDAC) Activity

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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exogenous ketone supplement

Participants will consume a ketone monoester supplement (KetoneAid KE4) at a dose of 0.75 g/kg of body weight.

Group Type EXPERIMENTAL

Ketone Monoester (KE)

Intervention Type DIETARY_SUPPLEMENT

Participants will receive an exogenous ketone supplement (KetoneAid KE4) in a fasted state in the morning, at a dosage of 0.75 g/kg of body weight.

Interventions

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Ketone Monoester (KE)

Participants will receive an exogenous ketone supplement (KetoneAid KE4) in a fasted state in the morning, at a dosage of 0.75 g/kg of body weight.

Intervention Type DIETARY_SUPPLEMENT

Other Intervention Names

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Exogenous ketone

Eligibility Criteria

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Inclusion Criteria

* Over the age of 19
* Able to fast overnight

Exclusion Criteria

* Being a competitive endurance athlete.
* Following a ketogenic diet, low-calorie diet, periodic fasting regimen, or regularly consuming ketogenic supplements.
* Being unable to travel to and from the university
* Being pregnant.
* Having been diagnosed with a chronic disorder of glucose or fat metabolism, including type 2 diabetes, chronic pancreatitis, or gallbladder disease
* Being unable to read or communicate in English.
Minimum Eligible Age

19 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of British Columbia

OTHER

Sponsor Role lead

Responsible Party

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Jonathan Little

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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University of British Columbia Okanagan Campus

Kelowna, British Columbia, Canada

Site Status RECRUITING

Countries

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Canada

Central Contacts

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Jonathan Little Principal Investigator, Professor Little, Ph.D

Role: CONTACT

250-807-9876

Facility Contacts

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Alexis Marcotte-Chénard Postdoctoral fellow, Ph.D

Role: primary

250-807-9876

Other Identifiers

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H24-02548

Identifier Type: -

Identifier Source: org_study_id

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