Evaluation of the Ketogenic Potential of Different Diet Supplements

NCT ID: NCT02693106

Last Updated: 2020-03-25

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

13 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-07-31

Study Completion Date

2015-06-30

Brief Summary

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Evaluate the capacity of different dietary supplements to increase ketone production in healthy adults.

Detailed Description

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The aim of this study is to evaluate the capacity of different dietary supplements to increase ketone production in healthy adults. Each supplement (leucine, butyrate, octanoate, carnitine or butter fraction rich in MCT) is evaluated for a period of 4-hour during which multiple blood samples are taken in order to measure ketone production.

Conditions

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Healthy Adults

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Ketogenic potential

Each participant has to go through a total of 8 visits, each visit corresponding to a standardize breakfast taken alone (control visit) or with one of the dietary supplements evaluated followed by a period of 4-hour with multiple blood sampling.

Intervention 1: Control; no supplement Intervention 2: 5 g of leucine Intervention 3: 3.6 g of butyrate Intervention 4: 7.2 g of butyrate Intervention 5: 5 g of octanoate Intervention 6: 10 g of octanoate Intervention 7: 1.95 g of carnitine Intervention 8: 65 g of butter fraction rich in MCT

Group Type EXPERIMENTAL

Control

Intervention Type DIETARY_SUPPLEMENT

Visit corresponding to a standardize breakfast taken alone (control visit) followed by a period of 4-hour with multiple blood sampling.

Leucine

Intervention Type DIETARY_SUPPLEMENT

Visit corresponding to a standardize breakfast with 5 g of leucine followed by a period of 4-hour with multiple blood sampling.

Butyrate -

Intervention Type DIETARY_SUPPLEMENT

Visit corresponding to a standardize breakfast with 3.6 g of butyrate followed by a period of 4-hour with multiple blood sampling.

Butyrate +

Intervention Type DIETARY_SUPPLEMENT

Visit corresponding to a standardize breakfast with 7.2 g of butyrate followed by a period of 4-hour with multiple blood sampling.

Octanoate -

Intervention Type DIETARY_SUPPLEMENT

Visit corresponding to a standardize breakfast with 5 g of octanoate followed by a period of 4-hour with multiple blood sampling.

Octanoate +

Intervention Type DIETARY_SUPPLEMENT

Visit corresponding to a standardize breakfast with 10 g of octanoate followed by a period of 4-hour with multiple blood sampling.

Carnitine

Intervention Type DIETARY_SUPPLEMENT

Visit corresponding to a standardize breakfast with 1.95 g of carnitine followed by a period of 4-hour with multiple blood sampling.

Butter fraction

Intervention Type DIETARY_SUPPLEMENT

Visit corresponding to a standardize breakfast with 65 g of butter fraction followed by a period of 4-hour with multiple blood sampling.

Interventions

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Control

Visit corresponding to a standardize breakfast taken alone (control visit) followed by a period of 4-hour with multiple blood sampling.

Intervention Type DIETARY_SUPPLEMENT

Leucine

Visit corresponding to a standardize breakfast with 5 g of leucine followed by a period of 4-hour with multiple blood sampling.

Intervention Type DIETARY_SUPPLEMENT

Butyrate -

Visit corresponding to a standardize breakfast with 3.6 g of butyrate followed by a period of 4-hour with multiple blood sampling.

Intervention Type DIETARY_SUPPLEMENT

Butyrate +

Visit corresponding to a standardize breakfast with 7.2 g of butyrate followed by a period of 4-hour with multiple blood sampling.

Intervention Type DIETARY_SUPPLEMENT

Octanoate -

Visit corresponding to a standardize breakfast with 5 g of octanoate followed by a period of 4-hour with multiple blood sampling.

Intervention Type DIETARY_SUPPLEMENT

Octanoate +

Visit corresponding to a standardize breakfast with 10 g of octanoate followed by a period of 4-hour with multiple blood sampling.

Intervention Type DIETARY_SUPPLEMENT

Carnitine

Visit corresponding to a standardize breakfast with 1.95 g of carnitine followed by a period of 4-hour with multiple blood sampling.

Intervention Type DIETARY_SUPPLEMENT

Butter fraction

Visit corresponding to a standardize breakfast with 65 g of butter fraction followed by a period of 4-hour with multiple blood sampling.

Intervention Type DIETARY_SUPPLEMENT

Other Intervention Names

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CTL

Eligibility Criteria

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Inclusion Criteria

* Healthy adults aged of 18 years old or older.
* Non-smoking.

Exclusion Criteria

* Diabetes or prediabetes
* Uncontrolled hypertension
* Uncontrolled thyroid function
* Taking medication that will affect lipid/glucose metabolism
* Severe infection or inflammation
* Pregnancy
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Université de Sherbrooke

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Stephen Cunnane, PhD

Role: PRINCIPAL_INVESTIGATOR

Research Centre on Aging CSSS-IUGS - CIUSSS de l'Estrie - CHUS

Locations

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Research Centre on Aging (CSSS-IUGS - CIUSSS de l'Estrie - CHUS)

Sherbrooke, Quebec, Canada

Site Status

Countries

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Canada

Other Identifiers

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2014-387

Identifier Type: -

Identifier Source: org_study_id

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