Carnitine Supplementation and Skeletal Muscle Function

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

View full results

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

28 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-02-29

Study Completion Date

2017-07-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Research project objectives The primary aim of the current research project is to use carnitine supplementation as the anti-inflammatory intervention for exploring the relationship between inflammation and associated with aging reduction of skeletal muscle mass.

Hypothesis The carnitine supplementation modulates the blood cytokines concentration. Anti-inflammatory intervention delay the reduction of skeletal muscle mass associated with aging

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Carnitine Supplementation and Skeletal Muscle Mass

NCT05009641

Muscle Loss

COMPLETED NA

Effect of CoQ10 on the Endocrine Function of Skeletal Muscle

NCT05412888

Ischemic Preconditioning Coenzyme Q Deficiency Exercise Training

NOT_YET_RECRUITING NA

The Effect of Antioxidant Vitamin Supplementation on Muscle Performance and Redox Status After Eccentric Training

NCT01290458

Muscle Damage Oxidative Stress Hemolysis

COMPLETED NA

Dietary Macronutrient Manipulation and Substrate Oxidation During Exercise

NCT02605291

Dietary Manipulation

COMPLETED NA

Effects of Creatine Supplementation on Muscle Mass and Function Among Older Women Subjected to Resistance Training

NCT02188849

Muscle Weakness

COMPLETED PHASE3

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Volunteers over 65 years old (n=40) are supplemented either with carnitine or placebo for 24 weeks. Before the start, in the mid-point, and after finishing the supplementation the following primary outputs variables are performed: body composition analysis (InBody720), maximal isokinetic knee extensor peak torque (Biodex System 4 Pro), blood cytokines and carnitine concentration, blood lipid profile.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Sarcopenia

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

carnitine

24 weeks l-carnitine-l-tartrate supplementation

Group Type EXPERIMENTAL

carnitine

Intervention Type DIETARY_SUPPLEMENT

1500 mg/d l-carnitine-l-tartrate

placebo

24 weeks isonitrogenous supplementation

Group Type PLACEBO_COMPARATOR

placebo

Intervention Type DIETARY_SUPPLEMENT

isonitrogenous

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

carnitine

1500 mg/d l-carnitine-l-tartrate

Intervention Type DIETARY_SUPPLEMENT

placebo

isonitrogenous

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Subjects with no history of gastrointestinal disorders, cardiovascular disease or hypertension.

Exclusion Criteria

* Subjects having any illnesses and a history of gastrointestinal disorder, cardiovascular disease, hypertension, liver and renal disease, diabetes, cancer, alcoholism or other metabolic diseases.

Minimum Eligible Age

65 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes