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Polyphenol Rich Supplementation on Markers of Recovery From Intense Resistance Exercise

NCT ID: NCT03540602

Last Updated: 2018-05-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE1

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-05-01

Study Completion Date

2018-08-31

Brief Summary

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Strength training is commonly used as an intervention to increase muscle mass, thus improving a person's ability to undertake activities of daily living, or enhance athletic performance. The strength training regimen itself, while ultimately having beneficial effects, causes muscle fibers to be damaged, which the body has to recover from. As the body recovers, it rebuilds the muscle tissue and after multiple consecutive bouts of strength training, the muscle eventually becomes larger and stronger. Thus, it is the recovery from strength training exercise that ultimately determines how well the body adapts. Where inadequate recovery could eventually lead to overtraining and/or injury, optimizing the recovery process from strength training could maximize strength training adaptations. This concept of optimizing recovery has led to development of many supplements, including antioxidants, which may reduce the damage associated with strength training activities and therefore enhance positive adaptations. The purpose of this study is to assess the ability of a polyphenol rich supplementation to aid the recovery process from a demanding bout of resistance exercise

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Detailed Description

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Conditions

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Muscle Soreness

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

20 male participants will start with a familiarization visit where they will receive either the placebo supplement or the polyphenol rich supplement that they will take for 7 days. After taking the supplement, the participants will come back and run through the acute resistance exercise protocol as well as return the next day for a post test. Next, the participants will undergo a "wash out" phase where they will not take any supplementation. At the end of these 2 weeks, the participants will then take the other supplement (i.e. if they took the polyphenol rich supplement in the first phase they will take the placebo supplement in the second phase). After a week of taking their assigned supplement, participants will complete the acute resistance exercise protocol and the post test.
Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

DOUBLE

Participants Investigators
To ensure that all subjects and researchers are unaware of the treatment assignments we will have one outside individual that will possess the knowledge of which subjects are given which supplement and which were given a placebo. This information will remain confidential until the study has been concluded. At the conclusion of the study, participants will be informed of which condition they were assigned. in an event of an emergency or the participant decides not to participate his condition will be revealed.

Study Groups

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Placebo

Rice flour capsule

Group Type PLACEBO_COMPARATOR

Placebo Oral Capsule [CEBOCAP]

Intervention Type OTHER

Rice flour

Polyphenol Rich Supplement

NordicCherry Tart Cherry Extract Powder 500 mg in capsule form

Group Type ACTIVE_COMPARATOR

Tart Cherry

Intervention Type DIETARY_SUPPLEMENT

NordicCherry Tart Cherry Extract Powder 500 mg from Specnova, inc

Interventions

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Tart Cherry

NordicCherry Tart Cherry Extract Powder 500 mg from Specnova, inc

Intervention Type DIETARY_SUPPLEMENT

Placebo Oral Capsule [CEBOCAP]

Rice flour

Intervention Type OTHER

Other Intervention Names

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NordicCherry Tart Cherry Extract Powder 500 mg

Eligibility Criteria

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Inclusion Criteria

* 6 months of resistance training experience with barbel back squat exercise

Exclusion Criteria

* Not currently taking any antioxidant supplements, not currently using any hormone replacement therapy or anabolic androgenic steroids.
Minimum Eligible Age

21 Years

Maximum Eligible Age

45 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Specnova, inc

UNKNOWN

Sponsor Role collaborator

Jacksonville University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Heather Hausenblaus

Role: PRINCIPAL_INVESTIGATOR

Jacksonville University

Locations

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Jacksonville University

Jacksonville, Florida, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Heather Hausenblaus

Role: CONTACT

[email protected]
904-256-7975

David Hooper

Role: CONTACT

[email protected]
904-256-7985

Facility Contacts

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Heather Hausenblaus, PhD

Role: primary

[email protected]
410-256-7975

David Hooper, PhD

Role: backup

[email protected]
904-256-7985

References

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Reid MB. Invited Review: redox modulation of skeletal muscle contraction: what we know and what we don't. J Appl Physiol (1985). 2001 Feb;90(2):724-31. doi: 10.1152/jappl.2001.90.2.724.

Reference Type BACKGROUND
PMID: 11160074 (View on PubMed)

Alessio HM, Goldfarb AH, Cutler RG. MDA content increases in fast- and slow-twitch skeletal muscle with intensity of exercise in a rat. Am J Physiol. 1988 Dec;255(6 Pt 1):C874-7. doi: 10.1152/ajpcell.1988.255.6.C874.

Reference Type RESULT
PMID: 3202155 (View on PubMed)

Blair SN, Cheng Y, Holder JS. Is physical activity or physical fitness more important in defining health benefits? Med Sci Sports Exerc. 2001 Jun;33(6 Suppl):S379-99; discussion S419-20. doi: 10.1097/00005768-200106001-00007.

Reference Type RESULT
PMID: 11427763 (View on PubMed)

Powers SK, Jackson MJ. Exercise-induced oxidative stress: cellular mechanisms and impact on muscle force production. Physiol Rev. 2008 Oct;88(4):1243-76. doi: 10.1152/physrev.00031.2007.

Reference Type RESULT
PMID: 18923182 (View on PubMed)

Other Identifiers

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Polyphenol Supplementation

Identifier Type: -

Identifier Source: org_study_id

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