Effects of N-acetyl Cystein (NAC) Supplementation in G6PD Deficient Individuals After Acute Exercise
NCT ID: NCT02937376
Last Updated: 2022-01-05
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
EARLY_PHASE1
12 participants
INTERVENTIONAL
2023-02-01
2023-11-01
Brief Summary
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Detailed Description
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Participants will perform 4 trials of exercise (70% VO2max for 45min and 90% till exhaustion) before and after each condition. Blood samples will be collected before, immediately after and 1 hour after exercise. Moreover, measurements of anthropometric characteristics and physiological parameters will be performed before and after each condition. There will be a washout period of at 4 weeks between conditions.
Conditions
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Study Design
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RANDOMIZED
CROSSOVER
TREATMENT
QUADRUPLE
Study Groups
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N-acetyl Cystein
NAC supplementation (10 mg/kg/day) for 4 weeks in a counterbalanced manner to 12 G6PD deficient individuals.
N-acetyl cystein
A trial of exercise before and after 4 weeks of N-acetyl cystein (NAC) supplementation.
Placebo
Placebo administration for 4 weeks in a counterbalanced manner to 12 G6PD deficient individuals.
Placebo
A trial of exercise before and after 4 weeks of placebo administration.
Interventions
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N-acetyl cystein
A trial of exercise before and after 4 weeks of N-acetyl cystein (NAC) supplementation.
Placebo
A trial of exercise before and after 4 weeks of placebo administration.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Current use of dietary supplements or drugs
* Pregnant, pregnancy intention or breast feeding
18 Years
65 Years
ALL
No
Sponsors
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University of Thessaly
OTHER
Responsible Party
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Athanasios Z. Jamurtas
Professor
Principal Investigators
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Athanasios Z Jamurtas, PhD
Role: STUDY_DIRECTOR
University of Thessaly
Locations
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Department of Physical Education & Sport Science of the University of Thessaly
Trikala, Karyes, Greece
Countries
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Central Contacts
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References
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Georgakouli K, Deli CK, Zalavras A, Fatouros IG, Kouretas D, Koutedakis Y, Jamurtas AZ. Alpha-lipoic acid supplementation up-regulates antioxidant capacity in adults with G6PD deficiency. Food Chem Toxicol. 2013 Nov;61:69-73. doi: 10.1016/j.fct.2013.01.055. Epub 2013 Feb 14.
Other Identifiers
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UTH_G6PD 2
Identifier Type: -
Identifier Source: org_study_id
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