Antioxidants Vitamins and Muscle Damage

NCT ID: NCT05127928

Last Updated: 2022-04-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

18 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-02-10

Study Completion Date

2022-03-06

Brief Summary

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Determine if acute supplementation with antioxidant vitamins (vitamin C and vitamin E) influences the muscle damage and fatigue caused after an acute session of eccentric training.

Detailed Description

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A randomized, single-blind, placebo-control parallel trial will be conducted. In a previous session volunteers will be interviewed to determine if they meet the inclusion criteria.

Participants should avoid ingesting of foods that contain high amounts of antioxidant compounds: more than two juices of fruits, more than four cups of coffee or tea. Juices with high antioxidant content should be avoided. Alcoholic beverages should also be avoided. Participants will be divided in to groups and will performance one resistance exercise sessions. Prior to exercise, one group will intake supplementation VitC (1000 mg) + VitE (235 mg) and the other supplementation with placebo.

The following sequence will be performed in each session: 1) baseline assessment (analysis of the composition body, blood draw and parameters of performance) prior to exercise session ; 2) administration of vitamin or placebo supplementation 2 hours before exercise session ; 3) post-exercise assessments (blood biomarkers and performance parameters) immediately after the session and after 24 hours. DOMS will also be assessed 48 h and 72 h after training. The training session implemented will be designed by a Sport Scientific

Conditions

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Oxidative Stress

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Supplementation

Vitamin C and Vitamin E before exercise

Group Type EXPERIMENTAL

Dietary Supplement: Vitamin C and vitamin E

Intervention Type DIETARY_SUPPLEMENT

Antioxidant supplementation

Placebo

Placebo before exercise

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DIETARY_SUPPLEMENT

Placebo administration

Interventions

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Dietary Supplement: Vitamin C and vitamin E

Antioxidant supplementation

Intervention Type DIETARY_SUPPLEMENT

Placebo

Placebo administration

Intervention Type DIETARY_SUPPLEMENT

Other Intervention Names

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Ascorbic acid and tocopherol

Eligibility Criteria

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Inclusion Criteria

* Healthy
* Physically active

Exclusion Criteria

* Injuries
* Supplementation or drugs
* Smokers
Minimum Eligible Age

18 Years

Maximum Eligible Age

33 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Universidad Europea de Madrid

OTHER

Sponsor Role lead

Responsible Party

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María Martínez Ferrán

PhD student, principal investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Universidad Europea de Madrid

Madrid, , Spain

Site Status

Countries

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Spain

Other Identifiers

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CIPI/20/209-part2

Identifier Type: -

Identifier Source: org_study_id

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