The Effects of Exogenous Ketosis on Ultra-endurance Recovery and Performance
NCT ID: NCT06965491
Last Updated: 2025-05-11
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
24 participants
INTERVENTIONAL
2024-03-01
2025-10-30
Brief Summary
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Detailed Description
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Therefore, the purpose of the study is to create a better understanding of the exercise fatigue experienced during ultra-endurance performance and the role intermittent exogenous ketosis (IEK) plays in reducing the amount of fatigue to maintain performance during multi-day racing and lower the risk of injury and illness.
Participants will first compete in a 8-day simulated stage race performed on taxc trainers and then we will conduct a field study during the Absa Cape Epic a 8-day mountain bike stage race. Immediately following each stage and 30-mins before bed the participants will consume either a ketone ester and taste-match placebo drink. During the race the following variables will be measured; hydration status, weight change, activity readiness, and nutrition intake. Cognitive function will be assessed on day 2, 4 and 8 of racing. One day before and one day after the race the participants will report to the lab to assess basal metabolic rate, stress via questionnaires, appetite, cognitive function, muscle biopsies, venous blood samples, mechanical efficiency and 30-min Time Trial.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
BASIC_SCIENCE
DOUBLE
Study Groups
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Control group
Intervention: 8-day multistage mountain bike race/simulation Dietary intervention: placebo supplement (oral supplement containing: 16.4 grams of medium chained triglycerides, 1mM of sucrose octaacetate and water)
Placebo Supplement
Placebo supplement:
Oral supplement containing: 16.4 grams of medium chained triglycerides, 1mM or sucrose octaacetate and water
Experimental group
Intervention: 8-day multistage mountain bike race/simulation Dietary intervention: ketone ester supplement (25 grams of pure R-(3)-hydroxybutyl-(R)-3-hydroxybutyrate ketone monoester drink)
Ketone ester supplement
Ketone ester supplement Oral supplement containing: 25 grams of pure (R)-3-hydroxybutyl-(R)-3-hydroxybutyrate ketone monoester drink
Interventions
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Placebo Supplement
Placebo supplement:
Oral supplement containing: 16.4 grams of medium chained triglycerides, 1mM or sucrose octaacetate and water
Ketone ester supplement
Ketone ester supplement Oral supplement containing: 25 grams of pure (R)-3-hydroxybutyl-(R)-3-hydroxybutyrate ketone monoester drink
Eligibility Criteria
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Inclusion Criteria
* have been cycling for a minimum of 7 hours per week for the 6 months leading up to the study
* additional for the field study: valid entry to the 2025 edition of the Absa Cape Epic
* non-smoker
Exclusion Criteria
* Have any metabolic or auto-immune disease that will influence their metabolism
* Take medication or supplements that is known to affect ketone supplement metabolism
* suffering from a recurring injury or illness from which they have not fully recovered that is a contr-indication to perform high-intensity exercise
* Unable to finish each stage
* Women: if they are pregnant or breastfeeding
18 Years
59 Years
ALL
Yes
Sponsors
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University of Stellenbosch
OTHER
KU Leuven
OTHER
Responsible Party
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Chiel Poffé
Assistant Professor
Principal Investigators
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Chiel Poffé
Role: PRINCIPAL_INVESTIGATOR
KU Leuven
Locations
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KU Leuven
Leuven, Vlaams-Brabant, Belgium
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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S68178
Identifier Type: -
Identifier Source: org_study_id
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