Cerebral Reorganization in Schizophrenia

NCT ID: NCT01781000

Last Updated: 2014-11-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

80 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-12-31

Study Completion Date

2014-04-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of this study is to reveal the specific effects of computer-aided cognitive training on cerebral reorganization in schizophrenia

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Impairment in cognitive functions is one of the main symptoms in schizophrenia and is currently one of the challenges in the treatment of the disease. In this study we compare effects of two computer-aided training programs. One focused on auditory perception and processing as a basic ability underlying higher order information processing. The other training focus on facial affect discrimination and working memory. Both trainings are computer-aided and time-intensive, including up to twenty sessions within four weeks.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Schizophrenia

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Participants

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Auditiory verbal discrimination training

Brain Fitness \& Brain Training- Posit Science

Group Type EXPERIMENTAL

Brain Fitness & Brain Training- Posit Science

Intervention Type BEHAVIORAL

Computer aided cognitive program designed for intensive training of auditory perception, memory and attention

Facial affect discrimination training

Behavioral: Facial Affect Training- FAT

Group Type EXPERIMENTAL

Facial Affect Training- FAT

Intervention Type BEHAVIORAL

Computer-aided cognitive program designed for intensive training of facial affect discrimination, memory and attention

Treatment as usual

standard treatment/rehabilitation protocol of schizophrenia ward

Group Type ACTIVE_COMPARATOR

Treatment as usual

Intervention Type BEHAVIORAL

standard treatment protocol of schizophrenia ward

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Brain Fitness & Brain Training- Posit Science

Computer aided cognitive program designed for intensive training of auditory perception, memory and attention

Intervention Type BEHAVIORAL

Facial Affect Training- FAT

Computer-aided cognitive program designed for intensive training of facial affect discrimination, memory and attention

Intervention Type BEHAVIORAL

Treatment as usual

standard treatment protocol of schizophrenia ward

Intervention Type BEHAVIORAL

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Clinical diagnosis of schizophrenia and disorders with psychotic features
* Intact auditory perception
* Intact visual perception

Exclusion Criteria

* Mental retardation
* Age over 60
* Insufficient German language knowledge
Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

University of Konstanz

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Prof. Dr. Brigitte Rockstroh

Prof. Dr.

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Brigitte Rockstroh, Prof. Dr.

Role: STUDY_CHAIR

University Konstanz

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

University of Konstanz

Konstanz, Baden-Wurttemberg, Germany

Site Status

Countries

Review the countries where the study has at least one active or historical site.

Germany

References

Explore related publications, articles, or registry entries linked to this study.

Popova P, Popov TG, Wienbruch C, Carolus AM, Miller GA, Rockstroh BS. Changing facial affect recognition in schizophrenia: effects of training on brain dynamics. Neuroimage Clin. 2014 Sep 4;6:156-65. doi: 10.1016/j.nicl.2014.08.026. eCollection 2014.

Reference Type BACKGROUND
PMID: 25379427 (View on PubMed)

Related Links

Access external resources that provide additional context or updates about the study.

http://www.positscience.com/

Brain Training Software

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

RO805/142

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

Is Cognitive Training an Option?
NCT05352568 COMPLETED NA