Cognitive Remediation of Schizophrenia in a Community Mental Health Setting

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

112 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-09-30

Study Completion Date

2016-09-26

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of this study is to investigate the usefulness of neuroscience-guided cognitive training combined with community-based supported employment for people with schizophrenia. The investigators will examine the effectiveness of moving our study of neuroplasticity-based restorative targeted cognitive training out of the laboratory and into the community setting; and the investigators will also investigate its utility in enhancing functional outcome in chronically mentally ill adults who are participating in supported employment.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Optimizing Cognitive Remediation Outcomes in Schizophrenia

NCT02105779

Schizophrenia Psychosis

COMPLETED NA

Community-Based Cognitive Training in Early Schizophrenia

NCT01973270

Schizophrenia Psychosis

COMPLETED NA

Effectiveness of Targeted Cognitive Training for Neurological Deficits in People With Schizophrenia

NCT00312962

Schizophrenia

COMPLETED PHASE1/PHASE2

Feasibility of Providing Cognitive Remediation to People With Schizophrenia in a Clinical Network

NCT00930150

Schizophrenia

COMPLETED PHASE4

Evaluation of a Cognitive Adaptive E-treatment in Schizophrenia-diagnosed Adults

NCT01422902

Schizophrenia

COMPLETED PHASE2

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Neurocognitive functioning will be assessed at baseline (study entry), after cognitive training (6 months), and at 12 month follow-up, using the MATRICS Consensus Cognitive Battery (MCCB). The investigators will assess the following six constructs identified by MATRICS as separable, fundamental dimensions of cognitive impairment in schizophrenia, with a likely sensitivity to intervention \[26\]: 1) Speed of Processing, 2) Attention/Vigilance, 3) Working Memory, 4) Verbal Learning and Memory, 5) Visual Learning and Memory, and 6) Reasoning and Problem Solving (executive functioning). The investigators will also administer the delayed memory trials of HVLT and BVMT, Trails B, and D-KEFS Color-Word Interference Test \[27\], and will make one modification to the MCCB in utilizing BACS Tower of London \[28\] in place of NAB Mazes.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Experimental Condition TCT Controlled Condition CG

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Participants

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

(TCT) plus evidence-based SE

Group Type EXPERIMENTAL

(CG) plus evidence-based SE

Intervention Type OTHER

(CG) plus evidence-based SE

Group Type PLACEBO_COMPARATOR

(TCT) plus evidence-based SE

Intervention Type OTHER

Targeted cognitive computer training (TCT) plus evidence-based SE in a community setting

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

(TCT) plus evidence-based SE

Targeted cognitive computer training (TCT) plus evidence-based SE in a community setting

Intervention Type OTHER

(CG) plus evidence-based SE

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* diagnosis of schizophrenia or schizoaffective disorder(DSM-IV criteria)
* between the ages of 18-65
* English as primary language (learned before age 12)
* no major medical or neurological disorder that precludes participation in the study

Exclusion Criteria

* We will not exclude subjects with substance abuse or dependence as we wish to investigate the real-world effectiveness of this cognitive remediation approach when combined with SE. As per the clinical policy at Community Services, however, patients will not be permitted to attend the SE program or to participate in the study if they are acutely intoxicated. Subjects who miss 5 consecutive days of participation due to intoxication will be dropped and a replacement subject will be recruited.

Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No