Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
80 participants
INTERVENTIONAL
2013-05-31
2015-10-31
Brief Summary
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Cognitive deficits are a problem for many people with schizophrenia. This study will use computerized cognitive remediation training (which the participant can carry out at home) over a period of a few months.
Detailed Description
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1. Neuropsychological performance
2. Brain Structure using voxel-based morphometry (VBM)
3. Brain function using functional MRI (fMRI)
4. Social and occupational functioning
The cognitive remediation intervention is a computerised programme whose training level is dynamically varied to suit participants individual ability level. Motivation to learn and generalization to real world function are a particular focus of the intervention and are supported with ongoing therapist interaction in addition to personal training.
Conditions
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Keywords
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
TRIPLE
Study Groups
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Cognitive Remediation Therapy
Participants will undertake approximately 30 minutes of computerized CRT training for 8 weeks, 5 days per week. They will meet a therapist once per week to discuss any difficulties, help motivation.
Cognitive Remediation Therapy
Computerised training undertaken for approximately 30 minutes per day, 5 days per week for 8 weeks
Placebo Comparator
Participants will meet therapist once per week but will not undertake the Computerized Cognitive remediation training.
Placebo comparator
Participant meets the therapist once per week but does not carry out the CRT intervention. (Participants are subsequently offered the chance to carry out the CRT intervention post study if they so wish).
Interventions
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Cognitive Remediation Therapy
Computerised training undertaken for approximately 30 minutes per day, 5 days per week for 8 weeks
Placebo comparator
Participant meets the therapist once per week but does not carry out the CRT intervention. (Participants are subsequently offered the chance to carry out the CRT intervention post study if they so wish).
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* History of Psychosis
* Subjective difficulties with memory or concentration
* Aged 18-60 Years
Exclusion Criteria
* Substance misuse in the last 3 months
18 Years
60 Years
ALL
Yes
Sponsors
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Health Research Board, Ireland
OTHER
University of Dublin, Trinity College
OTHER
Responsible Party
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Gary Donohoe
Associate Professor
Principal Investigators
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Gary J Donoghoe, DClin Psych PhD
Role: PRINCIPAL_INVESTIGATOR
Trinity College Dublin, Ireland
Locations
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Department of Psychiatry, Trinity Centre for Health Sciences, St James Hospital, James St.
Dublin, Dublin, Ireland
Countries
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Central Contacts
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Facility Contacts
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April H Hargreaves, PhD
Role: primary
Rachael Dillon, BSc
Role: backup
Other Identifiers
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CRT001
Identifier Type: -
Identifier Source: org_study_id