Cognitive Training for Patients With Schizophrenia

NCT ID: NCT01521026

Last Updated: 2023-07-05

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

69 participants

Study Classification

INTERVENTIONAL

Study Start Date

2003-09-30

Study Completion Date

2009-08-31

Brief Summary

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This research on cognitive training addresses the following questions:

1. Does cognitive training lead to improved cognition, functional abilities, psychiatric symptoms, treatment adherence, or quality of life in patients with psychoses?
2. What are the neurocognitive and non-cognitive factors that predict good outcomes following cognitive rehabilitation? In addition to verbal learning and memory, immediate verbal memory, vigilance, and executive functioning, the cognitive training intervention attempted to improve prospective memory ability (i.e., the ability to remember to do things in the future, such as take medications or attend a doctor's appointment).

Detailed Description

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Conditions

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Schizophrenia Schizoaffective Disorder Other Primary Psychotic Disorders

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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Cognitive Training

Cognitive training group

Group Type EXPERIMENTAL

Cognitive Training

Intervention Type BEHAVIORAL

12-week compensatory cognitive training in group format

Standard Pharmacotherapy

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Cognitive Training

12-week compensatory cognitive training in group format

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Primary psychotic disorder (including schizophrenia, schizoaffective disorder, psychotic mood disorder, or psychosis NOS)
* Age 18 or older
* Fluency in English

Exclusion Criteria

* Dementia
* Neurological conditions affecting cognition
* Mental retardation
* Substance use disorder within the past month
* Participation in other intervention trials
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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National Alliance for Research on Schizophrenia and Depression

OTHER

Sponsor Role collaborator

University of California, San Diego

OTHER

Sponsor Role lead

Responsible Party

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Elizabeth Twamley

Associate Professor of Psychiatry

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Elizabeth W Twamley, PhD

Role: PRINCIPAL_INVESTIGATOR

UCSD

Locations

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UCSD Outpatient Psychiatric Services

San Diego, California, United States

Site Status

Countries

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United States

References

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Twamley EW, Vella L, Burton CZ, Heaton RK, Jeste DV. Compensatory cognitive training for psychosis: effects in a randomized controlled trial. J Clin Psychiatry. 2012 Sep;73(9):1212-9. doi: 10.4088/JCP.12m07686. Epub 2012 Aug 7.

Reference Type DERIVED
PMID: 22939029 (View on PubMed)

Other Identifiers

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NARSAD Young Investigator

Identifier Type: -

Identifier Source: org_study_id

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