Functional Neuroimaging Effects of Cognitive Remediation Training
NCT ID: NCT00481156
Last Updated: 2018-05-04
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE3
30 participants
INTERVENTIONAL
2005-03-01
2007-02-28
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
BASIC_SCIENCE
SINGLE
Study Groups
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Patients: Cognitive Remediation
Patients in the cognitive REM condition attended up to 25 h of training in small groups over 4-6 weeks based on the approach to cognitive remediation described by Wexler and Bell (2005). Patients performed tasks designed to train attention and memory from the battery available within a computerized software package (CogPack Marker Software). This training protocol has been shown to improve memory and executive functioning in patients with schizophrenia (Sartory et al, 2005) and tasks chosen were designed to produce improved working memory and attention capacity in the treated group. In addition, patients in the REM group trained on the word N-back one to two times a week and on N-back tasks using a variety of other stimuli (such as faces) one to two times a week to support the generalization of working memory improvements.
Cognitive Remediation
Patients: Cognitive-Behavioral Social Skills Training
Patients in the CBSST group also attended up to 25 h of treatment but followed a manualized group therapy protocol (Granholm et al, 2005) using cognitive and behavioral therapy methods to increase patients' skills in symptom recognition, communication, problem solving, and relapse prevention. In both conditions, the facilitators interacted with the clients throughout small group (B4 patients) sessions: in the REM group, this mostly involved brief one-on-one discussions regarding task performance; in the CBSST condition, this interaction was in the context of the group milieu.
Cognitive Behavioral Social Skills Training
Controls: Retest control group
Estimate of normal brain functioning and retest effects
Retest in Health Controls
Pre/Post test performance and neuroimaging only
Interventions
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Cognitive Remediation
Cognitive Behavioral Social Skills Training
Retest in Health Controls
Pre/Post test performance and neuroimaging only
Eligibility Criteria
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Inclusion Criteria
* Stable outpatient
Exclusion Criteria
* History of neurological damage, disorder, or disease
18 Years
55 Years
ALL
Yes
Sponsors
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Minnesota Medical Foundation
OTHER
University of Minnesota
OTHER
Responsible Party
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Principal Investigators
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Angus W MacDonald, Ph.D.
Role: PRINCIPAL_INVESTIGATOR
University of Minnesota
Kelvin O Lim, Ph.D.
Role: PRINCIPAL_INVESTIGATOR
University of Minnesota
Locations
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University of Minnesota
Minneapolis, Minnesota, United States
Countries
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References
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Haut KM, Lim KO, MacDonald A 3rd. Prefrontal cortical changes following cognitive training in patients with chronic schizophrenia: effects of practice, generalization, and specificity. Neuropsychopharmacology. 2010 Aug;35(9):1850-9. doi: 10.1038/npp.2010.52. Epub 2010 Apr 28.
Other Identifiers
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CogRehab
Identifier Type: -
Identifier Source: secondary_id
0404M58647
Identifier Type: -
Identifier Source: org_study_id
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