Study Results
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Basic Information
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COMPLETED
NA
151 participants
INTERVENTIONAL
2008-12-31
2011-10-31
Brief Summary
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Cognitive deficits are a core feature in schizophrenia. Conventional treatments (antipsychotic medication and psychological treatments) have limited effects so cognitive remediation programs were designed to alleviate the problems. Interventions typically involve a variety of exercises in a paper and pencil or a computerized format with a growing number of specialized computer programs now being developed. However, many of these programs lack specificity which does not allow an individual's specific needs to be addressed. More targeted interventions might increase the effects of therapy so RECOS - COgnitive REmediation for Schizophrenia - was developed to fit this gap.
Methods: This is a multicenter, randomized, controlled study comparing patients aged 18 to 45 years suffering from schizophrenia according to DSM-IV-TR. RECOS will be compared to an already validated program (CRT).
220 patients will be randomized as follows :
* Arm 1 : RECOS (42 h)
* Arm 2 : CRT (42 h) The recruitment is performed by psychiatrists in Lyon, Paris, Clermont-de-l'Oise, Niort, Bordeaux, Ville-Evrard and Lausanne.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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RECOS: 42 hours CR, 14 week-treatment.
RECOS(Cognitive Remediation for Schizophrenia) exercises were designed by SBT Company and adapted by Vianin et al (2007) for specific use in schizophrenia. It includes computer based and paper and pencil exercises that target 5 main cognitive functions. RECOS modules focus on the relevant cognitive domains, which have been recommended by the MATRICS consensus. Each exercise has 10 difficulty levels. Allocation of the training modules in RECOS was determined according to the standard scores obtained in the comprehensive neuropsychological assessment. Each patient participated in the module corresponding to his/her most altered cognitive area.
cognitive remediation
RECOS: cognitive remediation for schizophrenia CRT: cognitive remediation therapy
CRT: 42 hours CR, 14 week-treatment
CRT (Cognitive Remediation Therapy) exercises are the ones used by Wykes et al (1999). The CRT method consists of 3 modules: flexibility, memory (A and B) and planning (A and B). Each module involves a series of paper and pencil exercises with parallel forms providing with gradual difficulty.
cognitive remediation
RECOS: cognitive remediation for schizophrenia CRT: cognitive remediation therapy
Interventions
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cognitive remediation
RECOS: cognitive remediation for schizophrenia CRT: cognitive remediation therapy
Eligibility Criteria
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Inclusion Criteria
* French speaker or French schooling since 7 years
* clinical stability
* diagnosis of schizophrenia
Exclusion Criteria
* history of neurological illness or trauma
* alcohol or drug dependence
* mental retardation
18 Years
45 Years
ALL
No
Sponsors
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Centre hospitalier Saint Jean de Dieu - ARHM
OTHER
Saint Anne's Hospital
OTHER
Hôpital le Vinatier
OTHER
Responsible Party
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Nicolas FRANCK, Pr
Professor (Claude Bernard University), head of department (Hôpital le Vinatier), principal investigator
Principal Investigators
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Nicolas Franck
Role: PRINCIPAL_INVESTIGATOR
Hôpital le Vinatier
References
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Franck N, Duboc C, Sundby C, Amado I, Wykes T, Demily C, Launay C, Le Roy V, Bloch P, Willard D, Todd A, Petitjean F, Foullu S, Briant P, Grillon ML, Deppen P, Verdoux H, Bralet MC, Januel D, Riche B, Roy P; Other members of the Cognitive Remediation Network; Vianin P. Specific vs general cognitive remediation for executive functioning in schizophrenia: a multicenter randomized trial. Schizophr Res. 2013 Jun;147(1):68-74. doi: 10.1016/j.schres.2013.03.009. Epub 2013 Apr 9.
Other Identifiers
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RECOS
Identifier Type: -
Identifier Source: org_study_id
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