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Efficacy of Repyflec Cognitive Remediation Group Training in Schizophrenia

NCT ID: NCT01279070

Last Updated: 2013-08-23

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

62 participants

Study Classification

INTERVENTIONAL

Study Start Date

2006-09-30

Study Completion Date

2011-03-31

Brief Summary

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The purpose of this study was to develop an integrative intervention for schizophrenia taking into account previous efficacious therapies. Thus, our aim was to evaluate the efficacy of our cognitive remediation group training: Problem Solving and Cognitive Flexibility training (REPYFLEC), focused to improve neurocognition and functioning in schizophrenia patients. We hypothesized that training executive function and metacognition would allow us to achieve improvements in neurocognition, functioning and psychiatric symptoms of patients with schizophrenia.

Detailed Description

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Conditions

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Indication for Modification of Patient Cognitive Status

Keywords

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Schizophrenia Cognitive remediation Group training Executive function Social functioning

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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REPYFLEC cognitive remediation training

REPYFLEC cognitive remediation as a Problem solving and Cognitive flexibility group training.

Group Type EXPERIMENTAL

Repyflec cognitive remediation training

Intervention Type BEHAVIORAL

Comparison of 32 Repyflec group sessions among 32 leisure group sessions where we stimulated non-specific cognitive perform.

Leisure group

Leisure group is a stimulating activity focused on socialization through group dynamics, board games, "coffee and talk".

Group Type ACTIVE_COMPARATOR

Repyflec cognitive remediation training

Intervention Type BEHAVIORAL

Comparison of 32 Repyflec group sessions among 32 leisure group sessions where we stimulated non-specific cognitive perform.

Interventions

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Repyflec cognitive remediation training

Comparison of 32 Repyflec group sessions among 32 leisure group sessions where we stimulated non-specific cognitive perform.

Intervention Type BEHAVIORAL

Other Intervention Names

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Cognitive remediation therapy Cognitive rehabilitation Cognitive training

Eligibility Criteria

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Inclusion Criteria

* Diagnosis of schizophrenia or schizoaffective disorder
* More than 2 years illness duration
* Literate
* Mini Mental Status Examination score over 24
* Global Assessment of Functioning scores between 40 and 70

Exclusion Criteria

* Current acute illness exacerbation
* Mental Retardation
* Neurological disorder which impairs cognition
* Currently participating in social skills training or cognitive remediation
* Change of antipsychotic medication one month before the trial or during the 40 study weeks
* Diagnosis of alcohol or drug dependence within 6 months of trial commencement.
Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Fundació Sant Joan de Déu

OTHER

Sponsor Role lead

Responsible Party

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Aida Farreny

Dr. Aida Farreny

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Aida Farreny, PhD Psycho.

Role: PRINCIPAL_INVESTIGATOR

Fundació Sant Joan de Déu

Locations

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Parc Sanitari Sant Joan de Déu

Sant Boi de Llobregat, Barcelona, Spain

Site Status

Countries

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Spain

Other Identifiers

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REPYFLEC Clinical Trial

Identifier Type: -

Identifier Source: org_study_id