Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
77 participants
INTERVENTIONAL
2006-01-31
2010-12-31
Brief Summary
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The purpose of this study is to determine the impact of a new Cognitive Remediation Therapy (CRT) on cognition, social autonomy, symptoms and brain functioning in patients with schizophrenia.
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Detailed Description
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In a 2 arms blind study versus sham,80 patients with schizophrenia were enrolled in a program consisting of 14 training sessions of 4 cognitive functions (attention/concentration, topological memory, logical reasoning, executive functions)by means REHACOM® software. Measures of cognitive functioning using the Cogtest® battery as well as social autonomy (Social Autonomy Scale, EAS) and schizophrenia symptoms (Positive And Negative Syndrome Scale, PANSS) were undertaken at the beginning and the end of the meetings of remediation.
Among those 80 participants, 30 patients to (15 active / 15 sham) were randomized to participate in an fMRI study in order to investigate the impact of such CRT program on brain functioning (n-back task before CRT and 3 months later).
Conditions
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Study Design
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RANDOMIZED
PARALLEL
SUPPORTIVE_CARE
SINGLE
Study Groups
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behavior therapy - CRT
behavior program consisting of 14 training sessions of 4 cognitive functions (attention/concentration, topological memory, logical reasoning, executive functions) by means REHACOM® software
cognitive remediation therapy
program consisting of 14 training sessions of 4 cognitive functions (attention/concentration, topological memory, logical reasoning, executive functions)by means REHACOM® software
non-CRT
no intervention
non-CRT
waiting list
Interventions
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cognitive remediation therapy
program consisting of 14 training sessions of 4 cognitive functions (attention/concentration, topological memory, logical reasoning, executive functions)by means REHACOM® software
non-CRT
waiting list
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* remitted symptoms
* french language
* informed consent
Exclusion Criteria
* only for second randomized patient participating in MRI study (n=30) : MRI counterindications
18 Years
40 Years
ALL
Yes
Sponsors
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University Hospital, Grenoble
OTHER
University Hospital, Clermont-Ferrand
OTHER
Hôpital le Vinatier
OTHER
Responsible Party
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Principal Investigators
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Thierry d'amato, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
Hopital le Vinatier
Locations
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Hôpital le vinatier
Bron, , France
Countries
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References
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Bor J, Brunelin J, d'Amato T, Costes N, Suaud-Chagny MF, Saoud M, Poulet E. How can cognitive remediation therapy modulate brain activations in schizophrenia? An fMRI study. Psychiatry Res. 2011 Jun 30;192(3):160-6. doi: 10.1016/j.pscychresns.2010.12.004. Epub 2011 May 2.
Other Identifiers
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2005-094B
Identifier Type: -
Identifier Source: org_study_id
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