Comparing Cognitive Remediation Approaches for Schizophrenia
NCT ID: NCT04123223
Last Updated: 2020-08-14
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
135 participants
INTERVENTIONAL
2019-11-01
2022-07-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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Restorative CR Intervention
The restorative remediation intervention will consist of a target of 50 hours (5 hours per week, 1 hour per day, over 3 months) of a sequence of computerized cognitive exercises designed to improve cognitive function through repeated drill-and-practice of exercises largely focused on attention, working memory and verbal episodic memory. Cognitive deficits will be directly targeted by these exercises. Exercises will be started at individually determined levels of difficulty at which each client will be successful, e.g., 80% accuracy. Task difficulty will be increased as performance improves.
Cognitive Remediation
Cognitive remediation (CR) is a behavioral treatment designed to address neurocognitive deficits through task practice and/or strategy acquisition.
Strategy CR Intervention
Participants in this intervention will be treated for 24 hours (2 hours per week, one day per week over 3 months) with Compensatory Cognitive Training (CCT). The therapy targets four cognitive domains: (a) prospective memory, (b) attention and vigilance, (c) learning and memory, and (d) executive function. The program is a group-based intervention that teaches strategies via interactive, game-like activities to maintain interest and enhance motivation and engagement.
Cognitive Remediation
Cognitive remediation (CR) is a behavioral treatment designed to address neurocognitive deficits through task practice and/or strategy acquisition.
Computer Games
Three months of 1-hour, 5-times per week, client-selected computer games.
Computer Games
Sham placebo treatment
Interventions
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Cognitive Remediation
Cognitive remediation (CR) is a behavioral treatment designed to address neurocognitive deficits through task practice and/or strategy acquisition.
Computer Games
Sham placebo treatment
Eligibility Criteria
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Inclusion Criteria
2. Stabilized on atypical antipsychotic medication for a minimum of 2 months prior to entry into the protocol.
3. A minimum of 2 months since discharge from last hospitalization.
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Exclusion Criteria
2. Mental retardation (Full Scale IQ\<70, as estimated by single word-reading from the WRAT and/or evidence of a history of services).
3. Traumatic brain injury with loss of consciousness for more than 10 minutes.
4. Presence or history of any neurologic illness.
5. Lack of proficiency in English
6. Criteria met for concurrent substance dependence,
7. Scoring within 1SD of healthy control performance (from published norms) on measures of visual vigilance, verbal learning, and working memory.
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18 Years
ALL
No
Sponsors
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Hartford Hospital
OTHER
National Institute of Mental Health (NIMH)
NIH
Wesleyan University
OTHER
Responsible Party
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Matthew M. Kurtz
Professor
Locations
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Institute of Living
Hartford, Connecticut, United States
River Valley Services
Middletown, Connecticut, United States
Countries
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Other Identifiers
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