Computer Assisted Cognitive Remediation Program in Schizophrenia

NCT ID: NCT01598220

Last Updated: 2012-05-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

135 participants

Study Classification

INTERVENTIONAL

Study Start Date

2002-09-30

Study Completion Date

2005-12-31

Brief Summary

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The purpose of this study is to determine whether computer-assisted cognitive remediation therapy is effective in the treatment of cognitive deficits in schizophrenia.

Detailed Description

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Schizophrenia can be considered a chronic illness that affects all aspects of daily life. Cognitive deficits seems to play a key role that interferes directly in the functional adaptation.

Cognitive remediation therapy (CRT) emerges as a psychological intervention that target cognitive impairment. But, the use of computerized or papel an pencil procedures for remediation cognitive deficits remains controversial. Nonetheless, computer tasks offer a number of advantages compared to those of paper and pencil. The most noteworthy advantages are to enhance patient's motivation just because the sensory variety that the exercises presented or the possibility to provide immediate feedback. Furthermore, the possibility to present custom-tailored and adapted tasks taking into accounts the patients deficits and their evolution in the process of the psychological therapy is another important feature of computer-assisted cognitive remediation therapy.

Conditions

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Schizophrenia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Participants

Study Groups

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Computer-assisted cognitive remediation therapy

Group Type EXPERIMENTAL

Computer-assisted cognitive remediation therapy

Intervention Type BEHAVIORAL

Comparison of two groups:

The experimental group performs 48 sessions of computer exercices designed to remedy cognitive domains(attention, speed of processing, working memory,reasoning and problem solving) frequently affected in schizophrenia.

The intervention has a period 6 months , two sessions a week. All exercises provided a visual or verbal feedback to immediately terminate the execution.In addition to, the therapist after the sessions interactively explain the results and the strategies employed by the patient.

attentional task

Group Type PLACEBO_COMPARATOR

attentional task

Intervention Type OTHER

The Control group performs 48 sessions of watching videos and answer questions about these videos, in a period of 6 months , two sessions a week.

Interventions

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Computer-assisted cognitive remediation therapy

Comparison of two groups:

The experimental group performs 48 sessions of computer exercices designed to remedy cognitive domains(attention, speed of processing, working memory,reasoning and problem solving) frequently affected in schizophrenia.

The intervention has a period 6 months , two sessions a week. All exercises provided a visual or verbal feedback to immediately terminate the execution.In addition to, the therapist after the sessions interactively explain the results and the strategies employed by the patient.

Intervention Type BEHAVIORAL

attentional task

The Control group performs 48 sessions of watching videos and answer questions about these videos, in a period of 6 months , two sessions a week.

Intervention Type OTHER

Other Intervention Names

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cognitive remediation therapy

Eligibility Criteria

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Inclusion Criteria

* DSM-IV (APA, 1994)criteria for schizophrenia disorder
* Estimated IQ of 85 or superior by Vocabulary subtest, Wechsler Adult Intelligence Scale-III (WAIS-III)
* Patients were considered sufficiently stable if they had a Global Assessment of Functioning Scale (GAF)score of 40 or superior and they maintained a stable dose and type of psychiatric medication for at least 1 moth prior to inclusion.

Exclusion Criteria

* Non presence of cognitive impairment confirmed by neurocognitive assessment
* Traumatic brain injury or history of neurologic illness.
* Electroconvulsive therapy in the last year.
* Psychiatric comorbidity.
* Plan to change medication during the trial.
Minimum Eligible Age

18 Years

Maximum Eligible Age

55 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Gemma Garrido García

OTHER

Sponsor Role lead

Responsible Party

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Gemma Garrido García

Efficacy study of a computer cognitive remediation program in patients with schizophrenia

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Gemma Garrido Garcia

Role: PRINCIPAL_INVESTIGATOR

Consorci Sanitari de Terrassa

Locations

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Consorci Sanitari de Terrassa

Terrassa, Barcelona, Spain

Site Status

Countries

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Spain

References

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Wykes T, Reeder C, Landau S, Everitt B, Knapp M, Patel A, Romeo R. Cognitive remediation therapy in schizophrenia: randomised controlled trial. Br J Psychiatry. 2007 May;190:421-7. doi: 10.1192/bjp.bp.106.026575.

Reference Type BACKGROUND
PMID: 17470957 (View on PubMed)

Grynszpan O, Perbal S, Pelissolo A, Fossati P, Jouvent R, Dubal S, Perez-Diaz F. Efficacy and specificity of computer-assisted cognitive remediation in schizophrenia: a meta-analytical study. Psychol Med. 2011 Jan;41(1):163-73. doi: 10.1017/S0033291710000607. Epub 2010 Apr 12.

Reference Type BACKGROUND
PMID: 20380784 (View on PubMed)

Other Identifiers

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CACR-2012-MT

Identifier Type: -

Identifier Source: org_study_id

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