Computerized Cognitive Training for Schizophrenia in Brazil
NCT ID: NCT02591498
Last Updated: 2018-01-17
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
PHASE3
100 participants
INTERVENTIONAL
2014-01-31
2019-12-31
Brief Summary
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Detailed Description
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The aim of this study is to perform a computerized cognitive training to improve attention, concentration, learning, clinical symptoms and quality of life in patients. The investigators are interested in testing the differential efficacy between a specific visual versus auditory computerized cognitive training and explore the biological markers that may be involved in these neuroplasticity based training processes.
The investigators will conduct a 40 hours computerized, adaptable, perception specific, cognitive training program in patients with schizophrenia. Patients will come for 1 hour, daily, and perform a visual or auditory training, or control games for about 2 months. Visual and auditory exercises are chosen to be the equivalent of one another and target cognitive domains such as divided attention, working memory and social cognition. Clinical, cognitive, emotional and biomarker data will be collected before the training, half way through, and after the training, to assess progress in several aspects of their functioning and biology.
The investigators hypothesize visual and auditory trainings will be effective as compared to the control games. They also expect that auditory training to be more efficient compared to the visual training because it targets sensory functions that are mostly impaired in schizophrenia, due to auditory hallucinations patients experience. The investigators also hypothesize that both trainings will improve clinical symptoms and quality of life. On a more exploratory analysis, the investigators expect to identify new biological markers of cognitive neuroplasticity, which they expect will differentiate visual and auditory paths.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
QUADRUPLE
Study Groups
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Auditory
Administration of 40 hours of auditory training exercises
Computerized cognitive training
Visual
Administration of 40 hours of visual training exercises
Computerized cognitive training
Video Games
Administration of 40 hours of commercial video games
Computerized cognitive training
Interventions
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Computerized cognitive training
Eligibility Criteria
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Inclusion Criteria
* age 18- 60 years
* Portuguese as primary language (learned before age 12)
* no major medical or neurological disorder that precludes participation in the study
Exclusion Criteria
* active substance dependence (DSM-IV criteria)
18 Years
60 Years
ALL
No
Sponsors
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Universidade Federal do Rio de Janeiro
OTHER
Responsible Party
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Rogerio Panizzutti
Associate professor
Principal Investigators
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Rogerio Panizzutti, M.D., Ph.D.
Role: PRINCIPAL_INVESTIGATOR
Universidade Federal do Rio de Janeiro
Locations
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Federal University of Rio de Janeiro
Rio de Janeiro, Rio de Janeiro, Brazil
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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