Training-induced Cerebral Reorganization in Schizophrenia

NCT ID: NCT00695708

Last Updated: 2010-04-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-01-31

Study Completion Date

2010-01-31

Brief Summary

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The purpose of this study is to reveal the effects of computer-aided cognitive-auditory training on cerebral reorganization in schizophrenia.

Detailed Description

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Impairment in cognitive functions is one of the main symptoms in schizophrenia and is currently one of the challenges in the treatment of the disease.

In this study we compare effects of two computer-aided training programs. One focused on auditory perception and processing as a basic ability underlying higher order information processing.

The other training involves a variability of cognitive abilities.

Both trainings are computer-aided and time-intensive, including up to twenty sessions within four weeks.

Conditions

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Schizophrenia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Blinding Strategy

SINGLE

Participants

Study Groups

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BFT

20 schizophrenic patients

Group Type EXPERIMENTAL

Brain Fitness Program

Intervention Type BEHAVIORAL

Computer-aided cognitive program designed for intensive training of auditory perception, memory and attention

CP

19 schizophrenic patients

Group Type ACTIVE_COMPARATOR

Cogpack

Intervention Type BEHAVIORAL

Computer-aided cognitive program for cognitive abilities

HCG

20 healthy age and sex matched subjects

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Brain Fitness Program

Computer-aided cognitive program designed for intensive training of auditory perception, memory and attention

Intervention Type BEHAVIORAL

Cogpack

Computer-aided cognitive program for cognitive abilities

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Clinical diagnosis of schizophrenia and disorders with psychotic features
* Intact hearing abilities

Exclusion Criteria

* Mental retardation
* Age over 60
* Insufficient German language knowledge
Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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German Research Foundation

OTHER

Sponsor Role collaborator

University of Konstanz

OTHER

Sponsor Role lead

Responsible Party

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University of Konstanz

Principal Investigators

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Brigitte Rockstroh, Prof. Dr.

Role: STUDY_CHAIR

University of Konstanz, Department of Psychology

Locations

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University of Konstanz

Konstanz, Baden Württenberg, Germany

Site Status

Countries

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Germany

References

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Popov T, Jordanov T, Rockstroh B, Elbert T, Merzenich MM, Miller GA. Specific cognitive training normalizes auditory sensory gating in schizophrenia: a randomized trial. Biol Psychiatry. 2011 Mar 1;69(5):465-71. doi: 10.1016/j.biopsych.2010.09.028. Epub 2010 Nov 18.

Reference Type DERIVED
PMID: 21092939 (View on PubMed)

Other Identifiers

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RO 805/14

Identifier Type: -

Identifier Source: org_study_id

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