Neurophysiological Evaluation of Schizophrenia Patients After Cognitive and Physical Intervention

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

4 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-11-30

Study Completion Date

2019-07-31

Brief Summary

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Neurophysilogical, neuropsychological evaluation and cognitive and physical training

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Detailed Description

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24 sessions (8 weeks, 3 times per week) of cognitive and physical training via computer. Each session consisted of 45 minutes of cognitive traing (BrainHQ platform https://www.brainhq.com/) and 45 minutes of physical training (FitForAll platform https://www.fitforall.gr/play/app/). Cognitive training included memory, attention, velocity, intelligence etc. Physical training included aerobic, strength flexibility and other excercises. All evaluations were performed 1-14 before the initiation of the interventions and 1-14 after their completion. Neurophysiological evaluation consisted of EEG with the use of 128 electrode-machine and the protocol included 5 minuted of eyes closed and 5 minutes of eyes open. Neuropsychological evaluation included Trail Making Test (A \& B), Verbal Fluency, Stroop test, Wechsler Memory - Cubes (visuospatial), MoCA, FAB (Screening for frontal damage) and Eyes Test (Theory of Mind). Also, the physical condition evaluation included 6-Minute Walking Distance (6MWD), ΒΜΙ, HandGrip Strength Test, Short Physical Performance Battery Protocol.

Conditions

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Schizophrenia

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

HEALTH_SERVICES_RESEARCH

Blinding Strategy

NONE

Study Groups

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Cognitive and Physical Training

24 sessions (8 weeks, 3 times per week) of computer based 45 minute cognitive and 45 minute physical training.

Group Type EXPERIMENTAL

Cognitive Training

Intervention Type OTHER

Cognitive training included memory, attention, velocity, intelligence

Physical Training

Intervention Type OTHER

Physical training included aerobic, strength, flexibility and balance.

Interventions

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Cognitive Training

Cognitive training included memory, attention, velocity, intelligence

Intervention Type OTHER

Physical Training

Physical training included aerobic, strength, flexibility and balance.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* a diagnosis of schizophrenia disorder according to ICD10 criteria
* clinically stable patients (no recent change in psychotropic medication except benzodiazepines)
* sufficient acculturation and fluency in Greek language
* assent of the attending physician for participation in the study

Exclusion Criteria

* co-morbidity with neurological disorders (e.g.epilepsy) or head injury
* a pathological or other somatic disorder that contraindicate physical exercise
* alcoholism and substance abuse within the previous 3 months (except caffeine and tobacco)
* abstainance from intervention for more than 12 days
* cognitive decline
* treated with Benzodiazepine

Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No