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Visual Exploration and Attention: Studies in Patients With Schizophrenia and Autism Spectrum Disorders

NCT ID: NCT00914030

Last Updated: 2016-08-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

140 participants

Study Classification

OBSERVATIONAL

Study Start Date

2009-06-30

Study Completion Date

2016-12-31

Brief Summary

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The aim of the protocol is to better understand the impairments in visual processing, as such impairments may induce social interaction difficulties in subjects with autism spectrum disorders (adults and children) and schizophrenia, like face exploration.The same protocol will be used for the three populations, each population being compared with matched controls. The explorations are designed to test two different hypotheses regarding the mechanisms of the visual perception difficulties of the two populations. Even though difficulties to extract the global form of objects have been described in both subjects with autism and schizophrenia, we will test two different hypotheses for the two populations. We will test the hypothesis that subjects with autism display an advantage for the processing of local information arising at an early level of processing, whereas disorders observed in patients with schizophrenia originate from attention disorders. The protocol includes three consecutive studies, each one being applied in each of the three populations.

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Detailed Description

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Conditions

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Autism Spectrum Disorders Schizophrenia

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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A1

Patients with schizophrenia

Neuropsychological evaluation

Intervention Type OTHER

Study one: global/local processing, with a neutral prime (stimulus influencing the processing of the subsequent stimulus)Study two: global/ local processing with a prime whose elements are collinear.Study three: global/local processing with a prime whose elements are not collinear

A2

Control subjects matched individually with patients with schizophrenia

Neuropsychological evaluation

Intervention Type OTHER

Study one: global/local processing, with a neutral prime (stimulus influencing the processing of the subsequent stimulus)Study two: global/ local processing with a prime whose elements are collinear.Study three: global/local processing with a prime whose elements are not collinear

B1

Adult subjects with autism

Neuropsychological evaluation

Intervention Type OTHER

Study one: global/local processing, with a neutral prime (stimulus influencing the processing of the subsequent stimulus)Study two: global/ local processing with a prime whose elements are collinear.Study three: global/local processing with a prime whose elements are not collinear

B2

Control subjects matched individually with adult subjects with autism

Neuropsychological evaluation

Intervention Type OTHER

Study one: global/local processing, with a neutral prime (stimulus influencing the processing of the subsequent stimulus)Study two: global/ local processing with a prime whose elements are collinear.Study three: global/local processing with a prime whose elements are not collinear

C1

Children with autism

Neuropsychological evaluation

Intervention Type OTHER

Study one: global/local processing, with a neutral prime (stimulus influencing the processing of the subsequent stimulus)Study two: global/ local processing with a prime whose elements are collinear.Study three: global/local processing with a prime whose elements are not collinear

C2

Control subjects matched individually with children with autism

Neuropsychological evaluation

Intervention Type OTHER

Study one: global/local processing, with a neutral prime (stimulus influencing the processing of the subsequent stimulus)Study two: global/ local processing with a prime whose elements are collinear.Study three: global/local processing with a prime whose elements are not collinear

Interventions

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Neuropsychological evaluation

Study one: global/local processing, with a neutral prime (stimulus influencing the processing of the subsequent stimulus)Study two: global/ local processing with a prime whose elements are collinear.Study three: global/local processing with a prime whose elements are not collinear

Intervention Type OTHER

Other Intervention Names

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Each study will be conducted successively in each group (A1/ A2, B1/B2, C1/C2).

Eligibility Criteria

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Inclusion Criteria

* IQ above 70, as evaluated with the WAIS III in adults and with the WISC in children
* signed consent
* DSM IV criteria in case of autism spectrum disorders or schizophrenia

Exclusion Criteria

* grave or non stabilized somatic pathology
* pathology affecting the central nervous system; other than the studied pathologies
* intake of psychotropic drug, except for patients
* invalidating sensory processes
Minimum Eligible Age

7 Years

Maximum Eligible Age

55 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University Hospital, Strasbourg, France

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Anne GIERSCH

Role: PRINCIPAL_INVESTIGATOR

Institut National de la Santé Et de la Recherche Médicale, France

Locations

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Pôle départemental du Centre de Ressources Autisme pour adultes (67) - Etablissement public de santé Alsace-Nord (site de Brumath)

Brumath, , France

Site Status RECRUITING

Centre de Ressources Autisme Pôle adultes (68) - Espace Autisme 68

Colmar, , France

Site Status RECRUITING

Clinique Lautréamont

Loos, , France

Site Status RECRUITING

Pôle régional du Centre de Ressources Autisme pour enfants et adolescents - Unité d'évaluation des troubles du développement Hôpital de l'Elsau - Pôle de Psychiatrie - Unité d'évaluation des troubles du développement Hôpital de l'Elsau - HUS

Strasbourg, , France

Site Status RECRUITING

INSERM U666 ; Pôle de Psychiatrie - Service de Psychiatrie Adulte- HUS

Strasbourg, , France

Site Status RECRUITING

Countries

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France

Central Contacts

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GIERSCH Anne, MD

Role: CONTACT

[email protected]

Facility Contacts

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HOCHNER Arielle, MD

Role: primary

[email protected]

MURAD Ayman, MD

Role: primary

[email protected]

GONIN Olivier, MD

Role: primary

[email protected]

GRAS-VINCENDON Agnès, MD

Role: primary

[email protected]

GIERSCH Anne, MD

Role: primary

[email protected]

Other Identifiers

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2008-A01459-46

Identifier Type: -

Identifier Source: org_study_id

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