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Visual Information Processing in Schizophrenia Patients With Visual Hallucinations

NCT ID: NCT03188133

Last Updated: 2017-10-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

90 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-10-17

Study Completion Date

2020-10-31

Brief Summary

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Occurrence of visual hallucinations (VHs) in schizophrenia depend in part on disorders in the processing of late visual information (Top-Down). The broader question of how these top-down mechanisms (cognitive and / or emotional mechanisms) are involved in the occurrence of VHs remains to be specified and very few behavioral studies have so far been interested. The investigators propose to study the implication of Top-Down mechanisms in the visual hallucinatory manifestations, more specifically in the processing of ambiguous stimuli during an emotional priming task. Schizophrenia patients with VHs would have more false visual perceptions in the treatment of ambiguous stimuli than schizophrenia patients with auditory hallucinations or no hallucinations (AH/NH) and healthy controls.

Detailed Description

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In schizophrenia patients with auditory hallucinations, top-down mechanism on perceptual processing could be illustrated by tasks of listening to white noise. These studies show that psychotic subjects detect more words and phrases when exposed to these stimuli. In schizophrenia patients with VHs, to our knowledge no study have explored the mechanism of false perception. Thus, we propose to experimentally manipulate the implication of Top-Down mechanisms on visual perception using an emotional priming task. This paradigm has already been used in this population to explain the mechanisms underlying productive symptoms. For example, in an emotional priming task authors have shown that a negative valence primer contributes to the implementation of an interpretive bias in a confidence judgment task.

The aim of the present study is to explore the implication of these Top-Down mechanisms in hallucinatory manifestations, more specifically on the treatment of ambiguous visual stimuli during an emotional priming task by manipulating the emotional valence of the primer. The goal is to determine how emotional environmental elements contribute to the formation of erroneous perceptions in patients with schizophrenia with VHs.

Conditions

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Schizophrenia Visual Hallucination Auditory Hallucination False Perception

Keywords

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Schizophrenia Visual Hallucination False Perception emotional priming

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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VH

schizophrenia patients with visual hallucinations

Group Type EXPERIMENTAL

behavioral task : emotional priming

Intervention Type OTHER

emotional priming task on ambiguous visual stimuli

AH/NH

schizophrenia patients with auditory hallucinations or no hallucinations

Group Type ACTIVE_COMPARATOR

behavioral task : emotional priming

Intervention Type OTHER

emotional priming task on ambiguous visual stimuli

C

healthy controls

Group Type ACTIVE_COMPARATOR

behavioral task : emotional priming

Intervention Type OTHER

emotional priming task on ambiguous visual stimuli

Interventions

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behavioral task : emotional priming

emotional priming task on ambiguous visual stimuli

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

Group of patients with schizophrenia either with auditory hallucination (HA) but without visual hallucination (HV) or no hallucination, auditory or visual (NH) (HA / NH group)

* Schizophrenia according to the Diagnostic and Statistical Manual of Mental Disorders IV criteria
* Presence of a hallucinatory symptomatology in auditory mode (HA) in the history of the disease measured by the PSAS or absence of any hallucinatory manifestations in the history of the disease
* Absence of visual hallucinatory symptomatology (HV) in the history of the disease as measured by PSAS
Minimum Eligible Age

18 Years

Maximum Eligible Age

55 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Central Hospital, Nancy, France

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Vincent LAPREVOTE

Role: PRINCIPAL_INVESTIGATOR

Central hospital Nancy, Centre Psychothérapique de Nancy

Central Contacts

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Vincent LAPREVOTE

Role: CONTACT

Phone: 0033+383926822

Email: [email protected]

Florent BERNARDIN

Role: CONTACT

Phone: 0033+383925034

Email: [email protected]

References

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Catalan A, Simons CJ, Bustamante S, Drukker M, Madrazo A, de Artaza MG, Gorostiza I, van Os J, Gonzalez-Torres MA. Novel evidence that attributing affectively salient signal to random noise is associated with psychosis. PLoS One. 2014 Jul 14;9(7):e102520. doi: 10.1371/journal.pone.0102520. eCollection 2014.

Reference Type BACKGROUND
PMID: 25020079 (View on PubMed)

Hoffman RE, Woods SW, Hawkins KA, Pittman B, Tohen M, Preda A, Breier A, Glist J, Addington J, Perkins DO, McGlashan TH. Extracting spurious messages from noise and risk of schizophrenia-spectrum disorders in a prodromal population. Br J Psychiatry. 2007 Oct;191:355-6. doi: 10.1192/bjp.bp.106.031195.

Reference Type BACKGROUND
PMID: 17906248 (View on PubMed)

Galdos M, Simons C, Fernandez-Rivas A, Wichers M, Peralta C, Lataster T, Amer G, Myin-Germeys I, Allardyce J, Gonzalez-Torres MA, van Os J. Affectively salient meaning in random noise: a task sensitive to psychosis liability. Schizophr Bull. 2011 Nov;37(6):1179-86. doi: 10.1093/schbul/sbq029. Epub 2010 Apr 1.

Reference Type BACKGROUND
PMID: 20360211 (View on PubMed)

Hooker CI, Tully LM, Verosky SC, Fisher M, Holland C, Vinogradov S. Can I trust you? Negative affective priming influences social judgments in schizophrenia. J Abnorm Psychol. 2011 Feb;120(1):98-107. doi: 10.1037/a0020630.

Reference Type BACKGROUND
PMID: 20919787 (View on PubMed)

Other Identifiers

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ID-RCB/2017-A01058-45

Identifier Type: -

Identifier Source: org_study_id