Emotion and Motivation in Patients With Psychosis

NCT ID: NCT02853019

Last Updated: 2025-08-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

NA

Total Enrollment

41 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-02-02

Study Completion Date

2025-06-01

Brief Summary

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Anhedonia and avolition reflect emotional and motivational disorders, respectively. However, if these disorders play a major role in the symptomatology of schizophrenia, their mechanisms remain poorly understood, and existing treatments are inefficient on these symptoms. The literature suggests that the impairment does not concern emotion or motivation per se, but rather their influence on cognition. This project aims at using recent advances in the fundamental domain to better understand the cognitive and neuronal mechanisms of the patients' alterations, and especially how emotion and motivation influence cognition in schizophrenia.

Detailed Description

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Conditions

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Schizophrenia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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Healthy volunteers

Healthy volunteers

Group Type SHAM_COMPARATOR

Electroencephalogram

Intervention Type OTHER

electrophysiological measurements (evoked potentials) based on neural activity when visualizing stimuli

Cognitive tasks

Intervention Type BEHAVIORAL

\- clinical scales and subjective assessments of emotional and motivational stimuli

subjective evaluation scales

Intervention Type BEHAVIORAL

\- clinical scales and subjective assessments of emotional and motivational stimuli

Patients with schizophrenia

Patients with schizophrenia

Group Type EXPERIMENTAL

Electroencephalogram

Intervention Type OTHER

electrophysiological measurements (evoked potentials) based on neural activity when visualizing stimuli

Cognitive tasks

Intervention Type BEHAVIORAL

\- clinical scales and subjective assessments of emotional and motivational stimuli

subjective evaluation scales

Intervention Type BEHAVIORAL

\- clinical scales and subjective assessments of emotional and motivational stimuli

Interventions

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Electroencephalogram

electrophysiological measurements (evoked potentials) based on neural activity when visualizing stimuli

Intervention Type OTHER

Cognitive tasks

\- clinical scales and subjective assessments of emotional and motivational stimuli

Intervention Type BEHAVIORAL

subjective evaluation scales

\- clinical scales and subjective assessments of emotional and motivational stimuli

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* diagnostic and Statistical Manual of Mental Disorders criteria for schizophrenia

Exclusion Criteria

* addiction problem
* invalidating visual sensory problems
* neurological history
* for the healthy volunteers: psychiatric history
Minimum Eligible Age

18 Years

Maximum Eligible Age

55 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Institut National de la Santé Et de la Recherche Médicale, France

OTHER_GOV

Sponsor Role collaborator

University Hospital, Strasbourg, France

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Unité INSERM 1114

Strasbourg, , France

Site Status

Countries

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France

Other Identifiers

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6152

Identifier Type: -

Identifier Source: org_study_id

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