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Perceptual Deficits in Schizophrenia

NCT ID: NCT02337439

Last Updated: 2017-11-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-08-31

Study Completion Date

2018-12-31

Brief Summary

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In this study, participants with schizophrenia and schizoaffective are given computer exercises to complete. The goals of the study are to determine whether: 1) any of the computer exercises can improve information processing problems in schizophrenia, 2) improvements in information processing are related to other cognitive improvements, and 3) there are changes in brain activity associated with using the computer exercises.

The study will involve clinical interviews, cognitive tests, and frequent computerized cognitive training over the course of 2 months. Some participants will also have electroencephalography, a non-invasive test that measures brain activity, to determine whether there are changes in brain activity with the computer training.

Detailed Description

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Schizophrenia is a disabling neurodevelopmental illness, affecting nearly 1% of the population. The disability of schizophrenia is due in large part to the effects of the illness on cognitive faculties. Current medications for schizophrenia do not generally improve cognition, so a major contribution to disability remains undertreated. Computerized cognitive remediation programs, which produce activity-dependent recruitment of neural resources to specifically enhance under-functioning brain systems, have been effective at improving both cognition and community functioning in patients with schizophrenia, but the effects are still modest. Our preliminary work has suggested that our training is associated with improvements in visual memory, though visual memory has been a cognitive area more refractory to cognitive training.

In this study, participants with schizophrenia or schizoaffective disorder will be randomized to receive different computer exercises to help determine whether computer exercises can improve memory in schizophrenia, and whether the cognitive training is associated with changes in neural activity.

Conditions

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Schizophrenia Schizoaffective Disorder

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Participants

Study Groups

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Sensory Information Processing Training

Computerized training designed to improve sensory processing

Group Type EXPERIMENTAL

Sensory Information Processing Training

Intervention Type BEHAVIORAL

Computer exercises requiring identification of visual stimuli on computer screen and response with keyboard

Active Control Training

Commercially available computer exercises that were not designed specifically to improve sensory information processing.

Group Type ACTIVE_COMPARATOR

Active Control Training

Intervention Type BEHAVIORAL

Commercially available educational software

Interventions

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Sensory Information Processing Training

Computer exercises requiring identification of visual stimuli on computer screen and response with keyboard

Intervention Type BEHAVIORAL

Active Control Training

Commercially available educational software

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* schizophrenia or schizoaffective disorder
* English speaking and reading

Exclusion Criteria

* current substance abuse
* visual impairment
* neurological conditions
* current enrollment in another research study
Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Brain & Behavior Research Foundation

OTHER

Sponsor Role collaborator

VA Connecticut Healthcare System

FED

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Yale University School of Medicine

New Haven, Connecticut, United States

Site Status

Countries

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United States

References

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Tandon R, Keshavan MS, Nasrallah HA. Schizophrenia, "just the facts" what we know in 2008. 2. Epidemiology and etiology. Schizophr Res. 2008 Jul;102(1-3):1-18. doi: 10.1016/j.schres.2008.04.011. Epub 2008 Jun 2.

Reference Type BACKGROUND
PMID: 18514488 (View on PubMed)

Green MF. What are the functional consequences of neurocognitive deficits in schizophrenia? Am J Psychiatry. 1996 Mar;153(3):321-30. doi: 10.1176/ajp.153.3.321.

Reference Type BACKGROUND
PMID: 8610818 (View on PubMed)

Carpenter WT, Buchanan RW. Lessons to take home from CATIE. Psychiatr Serv. 2008 May;59(5):523-5. doi: 10.1176/ps.2008.59.5.523.

Reference Type BACKGROUND
PMID: 18451009 (View on PubMed)

McGurk SR, Twamley EW, Sitzer DI, McHugo GJ, Mueser KT. A meta-analysis of cognitive remediation in schizophrenia. Am J Psychiatry. 2007 Dec;164(12):1791-802. doi: 10.1176/appi.ajp.2007.07060906.

Reference Type BACKGROUND
PMID: 18056233 (View on PubMed)

Wykes T, Huddy V, Cellard C, McGurk SR, Czobor P. A meta-analysis of cognitive remediation for schizophrenia: methodology and effect sizes. Am J Psychiatry. 2011 May;168(5):472-85. doi: 10.1176/appi.ajp.2010.10060855. Epub 2011 Mar 15.

Reference Type BACKGROUND
PMID: 21406461 (View on PubMed)

Surti TS, Wexler BE. A pilot and feasibility study of computer-based training for visual processing deficits in schizophrenia. Schizophr Res. 2012 Dec;142(1-3):248-9. doi: 10.1016/j.schres.2012.09.013. Epub 2012 Oct 6. No abstract available.

Reference Type BACKGROUND
PMID: 23043873 (View on PubMed)

Other Identifiers

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01856

Identifier Type: OTHER

Identifier Source: secondary_id

V1CDA2013-24

Identifier Type: -

Identifier Source: org_study_id