Normative Data for Cardiorespiratory Fitness in Healthy Adults

NCT ID: NCT07275619

Last Updated: 2025-12-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ENROLLING_BY_INVITATION

Total Enrollment

800 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-12-15

Study Completion Date

2026-07-31

Brief Summary

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Cardiorespiratory fitness (CRF) is a physical attribute which represents how effectively various bodily systems work together to transport and utilize oxygen to support muscular activity during prolonged, rhythmic, large-muscle, whole-body exercise. A key element associated with physical fitness is VO2max, which is referred to as cardiorespiratory fitness. Queen's college step test will be used to estimate the VO2max. This study will be cross sectional, normative study. Healthy adults aged 18-65 years from community setting will be recruited through non probability convenient sampling technique to collect data as per inclusion criteria. Sample size will be approximately 800, consist of equal ratio of males and females. Heart Rate, Recovery Heart Rate, VO2 max and METS will be calculated of each subject. Following equation is used to calculate VO2max, for females: VO2max = 65.81- \[0.1847× HR\] for males: VO2max = 111.33- \[0.42× HR\]. Data analysis will be conducted by using SPSS (Statistical Package for the Social Sciences) version 28.

Detailed Description

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Cardiorespiratory fitness (CRF) is a physical attribute which represents how effectively various bodily systems work together to transport and utilize oxygen to support muscular activity during prolonged, rhythmic, large-muscle, whole-body exercise. A key element associated with physical fitness is VO2max, which is referred to as cardiorespiratory fitness. Queen's college step test (reliability = 0.92, validity = 0.75) will be used to estimate the VO2max. The objectives of the study is to obtain the normative reference values for cardiorespiratory fitness in healthy pakistani adults.

This study will be cross sectional, normative study. Healthy adults aged 18-65 years from community setting will be recruited through non probability convenient sampling technique to collect data as per inclusion criteria. Sample size will be approximately 800, consist of equal ratio of males and females. Heart Rate, Recovery Heart Rate, VO2 max and METS will be calculated of each subject. Following equation is used to calculate VO2max, for females: VO2max = 65.81- \[0.1847× HR\] for males: VO2max = 111.33- \[0.42× HR\]. Demographics include Age (years), Height (m2), Weight (kg) and Body Mass Index (BMI kg/m2) will be measure for each subject.Data analysis will be conducted by using SPSS (Statistical Package for the Social Sciences) version 28.

Key words:

Adults, Cardiorespiratory fitness, Normative, Queen's college step test, VO2max

Conditions

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Healthy Adults

Study Design

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Observational Model Type

COHORT

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Cohort 1: 18 - 29 years

Cohort 1 will be approximately 200 consist of 100 males and 100 females. Subjects will be divided into cohort group according to their age. Queen's college step test will be used to estimate the VO2max

No interventions assigned to this group

Cohort 2: 30 - 41 years

Cohort 2 will be approximately 200 consist of 100 males and 100 females. Subjects will be divided into cohort group according to their age. Queen's college step test will be used to estimate the VO2max

No interventions assigned to this group

Cohort 3: 42 - 53 years

Cohort 3 will be approximately 200 consist of 100 males and 100 females. Subjects will be divided into cohort group according to their age. Queen's college step test will be used to estimate the VO2max

No interventions assigned to this group

Cohort 4: 54 - 65 years

Cohort 4 will be approximately 200 consist of 100 males and 100 females. Subjects will be divided into cohort group according to their age. Queen's college step test will be used to estimate the VO2max

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* • Pakistani Adults of age group 18-65 according to ACSM's guidelines

* Current healthy adults recruited by filling PAR\_Q test
* IPAQ short form will be administered, Participants scoring moderate or high activity level will be selected to perform QCST
* BMI ≥ 18.5 kg/m2 - ≤ 24.9 kg/m2
* Resting spO2 \>95%
* Resting heart rate ≥60bpm and ≤100bpm
* Mentally and physically fit adults without any physical, physiological and psychological issues

Exclusion Criteria

Presence of any acute/chronic illness Any cardiovascular, respiratory, neuromuscular, psychological, musculoskeletal or orthopedic condition and history of surgery Individuals taking any medical treatment History of active smoking
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Riphah International University

OTHER

Sponsor Role lead

Responsible Party

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Wajeeha Zia

Assistant Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Riphah International University, Lahore

Lahore, Punjab Province, Pakistan

Site Status

Countries

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Pakistan

References

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Kunutsor SK, Isiozor NM, Myers J, Seidu S, Khunti K, Laukkanen JA. Baseline and usual cardiorespiratory fitness and the risk of chronic kidney disease: A prospective study and meta-analysis of published observational cohort studies. Geroscience. 2023 Jun;45(3):1761-1774. doi: 10.1007/s11357-023-00727-3. Epub 2023 Jan 17.

Reference Type BACKGROUND
PMID: 36646903 (View on PubMed)

Rossi Neto JM, Tebexreni AS, Alves ANF, Smanio PEP, de Abreu FB, Thomazi MC, Nishio PA, Cuninghant IA. Cardiorespiratory fitness data from 18,189 participants who underwent treadmill cardiopulmonary exercise testing in a Brazilian population. PLoS One. 2019 Jan 9;14(1):e0209897. doi: 10.1371/journal.pone.0209897. eCollection 2019.

Reference Type BACKGROUND
PMID: 30625200 (View on PubMed)

Kaminsky LA, Arena R, Myers J. Reference Standards for Cardiorespiratory Fitness Measured With Cardiopulmonary Exercise Testing: Data From the Fitness Registry and the Importance of Exercise National Database. Mayo Clin Proc. 2015 Nov;90(11):1515-23. doi: 10.1016/j.mayocp.2015.07.026. Epub 2015 Oct 5.

Reference Type BACKGROUND
PMID: 26455884 (View on PubMed)

Ekblom-Bak E, Ekblom O, Andersson G, Wallin P, Soderling J, Hemmingsson E, Ekblom B. Decline in cardiorespiratory fitness in the Swedish working force between 1995 and 2017. Scand J Med Sci Sports. 2019 Feb;29(2):232-239. doi: 10.1111/sms.13328. Epub 2018 Nov 15.

Reference Type BACKGROUND
PMID: 30351472 (View on PubMed)

Hills AP, Jayasinghe S, Arena R, Byrne NM. Global status of cardiorespiratory fitness and physical activity - Are we improving or getting worse? Prog Cardiovasc Dis. 2024 Mar-Apr;83:16-22. doi: 10.1016/j.pcad.2024.02.008. Epub 2024 Feb 27.

Reference Type BACKGROUND
PMID: 38417767 (View on PubMed)

Sloan RA. Estimated Cardiorespiratory Fitness and Metabolic Risks. Int J Environ Res Public Health. 2024 May 16;21(5):635. doi: 10.3390/ijerph21050635.

Reference Type BACKGROUND
PMID: 38791849 (View on PubMed)

Dourado VZ, Nishiaka RK, Simoes MSMP, Lauria VT, Tanni SE, Godoy I, Gagliardi ART, Romiti M, Arantes RL. Classification of cardiorespiratory fitness using the six-minute walk test in adults: Comparison with cardiopulmonary exercise testing. Pulmonology. 2021 Nov-Dec;27(6):500-508. doi: 10.1016/j.pulmoe.2021.03.006. Epub 2021 May 4.

Reference Type BACKGROUND
PMID: 33958319 (View on PubMed)

Liu Y, Zhu J, Guo Z, Yu J, Zhang X, Ge H, Zhu Y. Estimated cardiorespiratory fitness and incident risk of cardiovascular disease in China. BMC Public Health. 2023 Nov 24;23(1):2338. doi: 10.1186/s12889-023-16864-5.

Reference Type BACKGROUND
PMID: 38001416 (View on PubMed)

Lang JJ, Prince SA, Merucci K, Cadenas-Sanchez C, Chaput JP, Fraser BJ, Manyanga T, McGrath R, Ortega FB, Singh B, Tomkinson GR. Cardiorespiratory fitness is a strong and consistent predictor of morbidity and mortality among adults: an overview of meta-analyses representing over 20.9 million observations from 199 unique cohort studies. Br J Sports Med. 2024 May 2;58(10):556-566. doi: 10.1136/bjsports-2023-107849.

Reference Type BACKGROUND
PMID: 38599681 (View on PubMed)

Related Links

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Other Identifiers

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nida naz

Identifier Type: -

Identifier Source: org_study_id

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