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The Age-related Changes of Energy Metabolism in Physically Fit Adult Males

NCT ID: NCT05113914

Last Updated: 2021-11-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

420 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-01-01

Study Completion Date

2019-12-20

Brief Summary

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The influence of age and physical fitness level on the level of energy metabolism and antioxidant capacity in adult males.

Detailed Description

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Over four hundred healthy, adult males of different age categories and physical fitness levels were included in the study. There is much research convincing that in athletes of various sports disciplines the level of energy metabolism, oxidative stress, and amino acid profiles during years of training undergoes sports adaptation. The study aimed to evaluate how age and physical fitness level affects the level of purine metabolites and metabolites of nicotinamide adenine dinucleotide, the level of antioxidant capacity, and amino acid profiles. Investigators hypothesized that there will be an age-related decline in most of the physiological indices, but significant differences will appear regarding the level of an individual's sports adaptation.

Conditions

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Healthy

Keywords

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athletes masters purine metabolites NAD metabolites CPET

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Healthy, physically fit men

All participants underwent a single CPET test with pre- and post-exercise blood measurements.

Group Type EXPERIMENTAL

Cardio-pulmonary exercise test

Intervention Type DIAGNOSTIC_TEST

An incremental running test was conducted on the treadmill. Initially, the exercise protocol included standing still for 3 min and walking for 3 min at a constant speed of 4 km/h. After this introductory part, the speed was increased to 8 km/h and then every 3 min by 2 km/h until the volitional exhaustion was reached. During all procedure oxygen consumption was measured with the use of a portable breath-by-breath ergospirometer.

Interventions

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Cardio-pulmonary exercise test

An incremental running test was conducted on the treadmill. Initially, the exercise protocol included standing still for 3 min and walking for 3 min at a constant speed of 4 km/h. After this introductory part, the speed was increased to 8 km/h and then every 3 min by 2 km/h until the volitional exhaustion was reached. During all procedure oxygen consumption was measured with the use of a portable breath-by-breath ergospirometer.

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

1. healthy
2. non-smoking
3. physically fit, including top-level athletes

Exclusion Criteria

1. no reported history of a cardiopulmonary or renal diseases, and other chronic diseases
2. no major orthopedic injury or illness resulting in an inability to run
3. no medications that could affect cardiopulmonary functions
4. normal resting electrocardiogram
5. body mass index (BMI) below 30.0 kg·m-2
6. normal erythrocyte count and Hb content
7. no pathological states known of significantly elevated adenylate pool and concentration of ATP, e.g. sickle cell disease, diabetes, leukemia, sepsis, tuberculosis, meningococcal infection, or renal insufficiency
Minimum Eligible Age

18 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Poznan University of Physical Education

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Jacek Zieliński, Prof.

Role: PRINCIPAL_INVESTIGATOR

Poznan University of Physical Education

Locations

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Poznan University of Physical Education

Poznan, , Poland

Site Status

Countries

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Poland

References

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Pospieszna B, Kusy K, Slominska EM, Zielinski J, Ciekot-Soltysiak M. Erythrocyte nicotinamide adenine dinucleotide concentration is enhanced by systematic sports participation. BMC Sports Sci Med Rehabil. 2024 Oct 15;16(1):216. doi: 10.1186/s13102-024-00999-y.

Reference Type DERIVED
PMID: 39407226 (View on PubMed)

Other Identifiers

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AWF_LA_MA865862

Identifier Type: -

Identifier Source: org_study_id