Using Platelet-rich Fibrin in Regenerative Endodontic Treatment in Mature Permanent Teeth
NCT ID: NCT07192289
Last Updated: 2025-09-25
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
NA
57 participants
INTERVENTIONAL
2025-09-15
2027-08-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
Experimental Group 2 - Regenerative endodontics using injectable platelet-rich fibrin (i-PRF).
TREATMENT
SINGLE
Interventions
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Using advanced platelet-rich fibrin (A-PRF+) or injectable platelet-rich fibrin (i-PRF) in regenerative endodontic treatment in mature permanent teeth.
After obtaining informed consent, the study will be conducted over 2 appointments, 2-4 weeks apart.
The first appointment will focus on infection control and inflammation reduction. The canal will be instrumented with a single-file system. The canal will be then irrigated sequentially with 3% sodium hypochlorite (NaOCl), saline, and 17% ethylenediaminetetraacetic Acid (EDTA) to ensure thorough disinfection. Finally, a temporary filling of Glass Ionomer Cement will be placed over an intracanal dressing of calcium hydroxide.
At the second appointment, the final treatment will be performed based on the patient's group:
Control Group - Blood clot method for regenerative endodontics. Experimental Group 1 - Regenerative endodontics using advanced platelet-rich fibrin (A-PRF+).
Experimental Group 2 - Regenerative endodontics using injectable platelet-rich fibrin (i-PRF).
All three groups will be then sealed with mineral trioxide aggregate (MTA) and a final composite resin filling.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* The root apex is not fully developed, or there is root resorption/cracking/fracture.
* The tooth has severe tooth loss and is indicated for extraction, or is indicated for restoration with a post or cast core after endodontic treatment.
* The root canal is calcified.
* The root canal curvature is greater than 25º.
* The tooth has a periapical cyst or is associated with a jawbone cyst.
* The tooth has a periodontal pocket deeper than 4 mm.
* The tooth has no occlusal contact.
* The patient is pregnant.
* The patient has diabetes or HIV or other immunocompromised conditions.
18 Years
ALL
Yes
Sponsors
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Odonto-Maxillo Facial Hospital in Ho Chi Minh City
UNKNOWN
University of Medicine and Pharmacy at Ho Chi Minh City
OTHER
Responsible Party
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Tran Thi Tuong Vi
Principal Investigator
Locations
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Odonto-Maxillo-Facial Hospital and University of Medicine and Pharmacy at Ho Chi Minh City
Ho Chi Minh City, Ho Chi Minh City, Vietnam
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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3787/QĐ-ĐHYD
Identifier Type: -
Identifier Source: org_study_id
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