Efficacy of Regenerative Endodontic Treatment With PRF as a Secondary Treatment of Mature Necrotic Incisors in Adolescents
NCT ID: NCT05517187
Last Updated: 2022-08-31
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
40 participants
INTERVENTIONAL
2022-03-10
2023-03-01
Brief Summary
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Twenty of of these permanent incisors will be treated with regenerative endodontic treatment(RET) with platelets rich fibrin PRF as intervention group vs. 20 incisors control group secondary treated with (RET) with induced blood clot (BC).
Detailed Description
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Eligibility criteria:
Healthy adolescents below the age of 18 years who need endodontic retreatment of previously obturated mature single-rooted incisors with gutta-percha will be recruited.
Patients with a positive history of allergic reactions, systemic diseases, and severe emotional or behavioral problems will be precluded. Only teeth diagnosed with asymptomatic apical periodontitis or chronic apical abscess (i.e. little discomfort with intermittent episodes of pus discharge through the sinus tract) were included. To confirm the clinical status, only teeth with a periapical index (PAI) score ≥3 based on Ørstavik et al classification were considered. Teeth with previous attempts for endodontic retreatment including pulpotomy or pulpectomy, non-restorable crowns or need post placement, or periodontal problems were excluded. A tooth must not be a candidate for endodontic surgery according to Glickman et al. indications and the updates of the European Society of Endodontology (e.g. obtaining biopsy, removal of intracanal broken files, persistent periapical lesions standing for a long period, radicular perforation, root fracture, or obstructed root canals, or the inability of complete removal of old gutta-percha or extruded material beyond the apex with persistent apical lesion for long duration).
Interventions:
According to the latest RET operating guidelines issued by the American Academy of Endodontics (AAE) and the European Society of Endodontics (ESE), the standardised operating procedure of RET requires two treatment visits. During the first appointment, infection is controlled and inflammation is relieved with complete removal of failed obturation material. Pulp regeneration and revascularization is accomplished during the second appointment.
Conditions
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Keywords
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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Blood Clot BC (Control arm)
Regenerative endodontic treatment with induced Blood Clot in root canal space as a secondary treatment for failed root canal treated incisors
no intervention
Regenerative endodontic treatment induced with blood clot in root canal space as a secondary treatment for failed root canal treated incisors
Platelets Rich Fibrin PRF (Intervention)
Regenerative endodontic treatment with Platelet- rich fibrin in root canal space as a secondary treatment for failed root canal treated incisors
Platelet rich fibrin
Regenerative endodontic treatment with platelet rich fibrin in root canal space as a secondary treatment for failed root canal treated incisors
Interventions
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no intervention
Regenerative endodontic treatment induced with blood clot in root canal space as a secondary treatment for failed root canal treated incisors
Platelet rich fibrin
Regenerative endodontic treatment with platelet rich fibrin in root canal space as a secondary treatment for failed root canal treated incisors
Eligibility Criteria
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Inclusion Criteria
2. Need endodontic retreatment of previously obturated closed apexes single-rooted incisors with gutta-percha.
3. No previous attempts for endodontic retreatment.
4. Presence of clinical signs and symptoms of chronic apical periodontitis
Exclusion Criteria
2. Teeth with previous attempts for endodontic retreatment including pulpotomy or pulpectomy, non-restorable crowns
11 Years
18 Years
ALL
Yes
Sponsors
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Nahda University
OTHER
Responsible Party
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Yassmine mohamed farouk el makawi
Lecturer in pediatric dentistry(clinical investigator)
Locations
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Nahda University
Banī Suwayf, , Egypt
Nahda
Cairo, , Egypt
Countries
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Central Contacts
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Facility Contacts
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Yasmin
Role: primary
Yasmin
Role: primary
Other Identifiers
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284
Identifier Type: -
Identifier Source: org_study_id