Clinical and Radiographic Evaluation of Advanced Platelet Rich Fibrin in the Preservation of Alveolar Ridge Following Atraumatic Tooth Extraction

NCT ID: NCT04197895

Last Updated: 2019-12-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

36 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-01-01

Study Completion Date

2020-12-20

Brief Summary

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compare the effect of application of A-PRF in socket preservation after atraumatic tooth extraction and natural healing regarding to bone remodeling . Null hypotheis, after atraumatic extraction, socket with advanced PRF has no difference with socket with blood clot in primary outcome

Detailed Description

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Conditions

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Socket Preservation

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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test group

Socket preservation with APRF

Group Type EXPERIMENTAL

Socket preservation with APRF

Intervention Type PROCEDURE

Socket preservation with APRF , A-PRF membranes were implanted into the extraction socket following tooth extraction. One entire A-PRF membrane would be placed at the base of the extraction socket and another A-PRF membrane will cover the extraction site then suturing will be done .Venous blood will be collected via venipuncture of the forearm with a butterfly needle into at least 10 mL sterile glass vacuum tube. The blood sample will be immediately centrifuged at 1,300 rpm (200 x g) for 8 minutes

control group

natural healing

Group Type ACTIVE_COMPARATOR

natural healing

Intervention Type PROCEDURE

after atraumatic extraction , the socket will be left for natural healing after suturing

Interventions

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Socket preservation with APRF

Socket preservation with APRF , A-PRF membranes were implanted into the extraction socket following tooth extraction. One entire A-PRF membrane would be placed at the base of the extraction socket and another A-PRF membrane will cover the extraction site then suturing will be done .Venous blood will be collected via venipuncture of the forearm with a butterfly needle into at least 10 mL sterile glass vacuum tube. The blood sample will be immediately centrifuged at 1,300 rpm (200 x g) for 8 minutes

Intervention Type PROCEDURE

natural healing

after atraumatic extraction , the socket will be left for natural healing after suturing

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* patients with an unremarkable medical history
* subjects with at least one site bordered by minimum of one tooth.
* Nonsmoker
* Teeth with root fracture, teeth with failed endodontic therapy or advanced caries
* Intact extraction socket with no dehiscence or fenestration.
* The buccolingual thickness of the buccal plate of bone in surgical area is 1 mm or more

Exclusion Criteria

* Patients with systemic diseases.
* Patients with presence or history of osteonecrosis of the jaws, with use of bisphosphonates, exposure to head and neck radiation, chemotherapy.
* patients with large distinct pre-apical pathology
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Nahed Gamal Saleh Abdelaal

OTHER

Sponsor Role lead

Responsible Party

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Nahed Gamal Saleh Abdelaal

dentist

Responsibility Role SPONSOR_INVESTIGATOR

Other Identifiers

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nana2019

Identifier Type: -

Identifier Source: org_study_id