Assessment of Regenerative Potential of Mature Permanent Teeth With Necrotic Pulps Using Two Revascularization Protocols. (In Vivo Study)

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-11-02

Study Completion Date

2020-11-02

Brief Summary

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Regenerative endodontic procedures have been used to successfully treat human mature permanent teeth with necrotic pulps and apical periodontitis. Many researchers have begun to apply regenerative endodontic procedures to mature teeth in adult patients. Several clinical case reports have shown complete resolution of signs and symptoms of pulp necrosis in mature teeth, even those with large periapical lesions, as well as signs of pulp canal obliteration. thevaim of this study is To assess the regenerative potential of mature permanent teeth with necrotic pulps with platelet-rich fibrin (PRF) and blood clot using radiographic and clinical methods.

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Detailed Description

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Conditions

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Apical Periodontitis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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Blood clotting protocol for pulp regeneration

pulp regeneration for mature teeth using blood clotting protocol

Group Type ACTIVE_COMPARATOR

Method

Intervention Type OTHER

treatment of mature teeth with apical periodontitis

platelet rich fibrin for pulp regeneration

pulp regeneration for mature teeth using platelet rich fibrin (PRF)

Group Type EXPERIMENTAL

Method

Intervention Type OTHER

treatment of mature teeth with apical periodontitis

Interventions

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Method

treatment of mature teeth with apical periodontitis

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Patients with mature teeth.
* Patients with periapical periodontitis.
* Maxillary anterior teeth only will be involved.
* Patients should be free from any systemic disease that may affect normal healing and predictable outcome.
* Patients who will agree to the consent and will commit to follow up period.

Exclusion Criteria

* Patients with immature roots.
* Patients with any systemic disease that may affect normal healing.
* Patients with swelling.
* Pregnant females.
* Patients who could/would not participate in a 1 year follow up.
* Patients with fistula.
* Patients with old age.
* Teeth with periodontal involvement.
* Teeth with vertical root fractures.
* Unrestorable teeth.

Minimum Eligible Age

11 Years

Maximum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes