Effect of Platelet-Rich Plasma Biomembrane on Enhancing Bone Regeneration Following Endodontic Surgery

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

15 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-11-24

Study Completion Date

2017-10-12

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This study was conducted to evaluate clinical and radiographical outcome of using a standardized platelet-rich plasma (PRP) biomembrane following endodontic surgery and its correlation with the growth factors content in this concentrate.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Comparison Between Emdogain and Amniotic Membrane as a Scaffold in Endodontic Regeneration of Immature Anterior Teeth

NCT07252167

Non-vital Immature Anterior Teeth

ACTIVE_NOT_RECRUITING NA

Pain After PRP Revascularization and Endodontic Treatment of Non-vital Mandibular Molars With Apical Periodontitis

NCT03350841

Postoperative Pain

UNKNOWN NA

Efficacy of Regenerative Endodontic Treatment With PRF as a Secondary Treatment of Mature Necrotic Incisors in Adolescents

NCT05517187

Dental Pulp Necroses

UNKNOWN NA

Using Platelet-rich Fibrin in Regenerative Endodontic Treatment in Mature Permanent Teeth

NCT07192289

Chronic Apical Periodontitis Necrosis of Pulp Acute Apical Periodontitis of Pulpal Origin +1 more

NOT_YET_RECRUITING NA

Healing Potentiality Of Blood Clot S-PRF and A-PRF in the Treatment Of Necrotic Mature Single-Rooted Teeth With Chronic Peri-Apical Periodontitis

NCT04606719

Necrotic Pulp

COMPLETED NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

15 healthy patients of both genders, between 20 and 45 years of age, presenting with 22 anterior/premolar teeth in need of endodontic surgery were recruited. Teeth presented with failed non-surgical root canal therapy and periapical radiolucency of ≥ 1cm in size. Patients were randomly divided following surgery into two groups, with 11 teeth each.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Endodontic Disease

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

osteotomy filled with PRP-gel and covered with PRP-biomembrane

the defect was filled with the previously activated autologous Platelet-rich plasma (PRP) gel and its supernatant. The site was then externally covered with the prepared bio-membrane composed of activated PRP which acted as an adjunct to the mucoperiosteal flap to stimulate tissue regeneration

Group Type EXPERIMENTAL

osteotomy filled with PRP-gel and covered with PRP-biomembrane

Intervention Type PROCEDURE

osteotomy site left empty

osteotomy site following the surgical intervention was left empty

Group Type SHAM_COMPARATOR

osteotomy site following the surgical intervention was left empty

Intervention Type PROCEDURE

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

osteotomy filled with PRP-gel and covered with PRP-biomembrane

Intervention Type PROCEDURE

osteotomy site following the surgical intervention was left empty

Intervention Type PROCEDURE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

1. Healthy patients.
2. Selected tooth with previous root canal therapy failure and in need of endodontic surgery.
3. Existence of a periapical radiographic lesion surrounding the root canal treated tooth, of size ≥ 1 cm.
4. Healthy periodontal condition (probing depth, mobility \& epithelial attachment level are all within normal range).