Treatment of Internal Inflammatory Root Resorption Using Injectable PRF Revascularization Technque

NCT ID: NCT04410679

Last Updated: 2021-10-08

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 10 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2018-06-03
• Study Completion Date: 2020-05-02

Brief Summary

Currently Endodontics looks forward for regeneration rather than repair. Regenerative endodontic therapy was limited to pulp revascularization of necrotic pulp in immature teeth , followed by mature teeth. Recently pulp revascularization technique by induction of blood clot was applied in the treatment of inflammatory root resorption. So far, no clinical study for management of teeth with inflammatory internal root resorption by using injectable PRF revascularization has been described in the literature. Thus, this is the first clinical attempt to manage inflammatory root resorption in necrotic incisor teeth using injectable PRF regenerative approach.

Detailed Description

13 teeth in a total of 10 patients with inflammatory root resorption will be treated using revascualrization technique, iPRF will be prepared and unjected in the canal after previous canal disinfection with calcium hydroxide for 2-4 weeks. cBCT will be taken preoperative and 12 month follow up period, also clinical and radiographic follow uo will be considered every 3 months for 1 year.

Conditions

Root Resorption

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

injectabl PRF for treatment of internal root resorption

Group Type: EXPERIMENTAL

injectable PRF

Intervention Type: BIOLOGICAL

blood sample and centrifuged to obtain i-PRF

Interventions

injectable PRF

blood sample and centrifuged to obtain i-PRF

Intervention Type: BIOLOGICAL

Eligibility Criteria

Inclusion Criteria

• patients 13-30 years old
• no sex predilection
• medically free
• Suffering from internal inflammatory root resorption in permanent anterior mature teeth
• associated with or without periapical radiolucency
• no or grade I tooth mobility, and a pocket depth <3 mm

Exclusion Criteria

• old age
• Medically medically compromised patients

• Minimum Eligible Age: 13 Years
• Maximum Eligible Age: 30 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Fayoum University

OTHER

Sponsor Role: lead

Responsible Party

Mohamed Nageh

Lecturer of Endodontics

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Mohamed Nageh, Lecturer

Role: PRINCIPAL_INVESTIGATOR

Faculty of dentistry, Fayoum University

Locations

Faculty of dentistry Fayoum University

Al Fayyum, , Egypt

Countries

Egypt

Other Identifiers

FayoumU

Identifier Type: -

Identifier Source: org_study_id