Study Results
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Basic Information
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COMPLETED
PHASE2
18 participants
INTERVENTIONAL
2017-07-01
2018-12-28
Brief Summary
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Detailed Description
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In the test group, rotary instrumentation was done using Pro-taper Next till size X3, while in the control group, instrumentation was done till size X5.
Calcium hydroxide was used as an intracanal medication for 1-2 weeks. Calcium hydroxide was then washed away using 1.5%NaOCl, followed by induction of blood using pre-curved K-fi;e #25 2mm past the radiographic apex. Biodentine was then used as a cervical plug over the blood clot followed by resin-modified glass ionomer cement and composite resin as coronal restoration.
MRI was used to assess the vitality of the regenerated pulp-like tissue, where the signal intensity of the regenerated pulp-like tissue was measured after 3,6 and 12 months follow up and compared to the normal contralateral teeth. In addition, sensibility tests using cold test and electric pulp testing were used to assess vitality of regenerated pulp-like tissue after 3,6,9 and 12 months. Cone beam computed tomography (CBCT) was also used to assess the healing of the periapical lesion after 12 months.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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Test group
The root canals were instrumented using Pro-taper next rotary files till size X3. REPs via blood clot using calcium hydroxide were then applied
Regenerative endodontic procedures (REPs)
Instrumentation using rotary Pro-Taper Next, disinfection using sodium hypochlorite and calcium hydroxide as intracanal medication followed by induction of blood and application of Biodentine as a cervical plug.
Control group
The root canals were instrumented using Pro-taper next rotary files till size X5. REPs via blood clot using calcium hydroxide were then applied.
Regenerative endodontic procedures (REPs)
Instrumentation using rotary Pro-Taper Next, disinfection using sodium hypochlorite and calcium hydroxide as intracanal medication followed by induction of blood and application of Biodentine as a cervical plug.
Interventions
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Regenerative endodontic procedures (REPs)
Instrumentation using rotary Pro-Taper Next, disinfection using sodium hypochlorite and calcium hydroxide as intracanal medication followed by induction of blood and application of Biodentine as a cervical plug.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Necrotic teeth
* Presence of periapical lesion.
Exclusion Criteria
* Presence of stainless steel wires o brackets
* Vital immature teeth with open apex
20 Years
40 Years
ALL
Yes
Sponsors
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Alexandria University
OTHER
Responsible Party
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Noha Mohamed El Kateb
Assistant lecturer, Faculty of dentistry
Locations
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Alexandria University
Alexandria, , Egypt
Countries
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References
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El-Kateb NM, Abdallah AM, ElBackly RN. Correlation between pulp sensibility and magnetic resonance signal intensity following regenerative endodontic procedures in mature necrotic teeth- a retrospective cohort study. BMC Oral Health. 2024 Mar 13;24(1):330. doi: 10.1186/s12903-024-04095-y.
Other Identifiers
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15012017
Identifier Type: -
Identifier Source: org_study_id
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