Efficacy of PRF and MTA as Compared to Calcium Hydroxide for Pulpotomy in Human Irreversibly Inflamed Permanent Teeth
NCT ID: NCT05266859
Last Updated: 2022-08-17
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE2
114 participants
INTERVENTIONAL
2019-08-28
2022-01-14
Brief Summary
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Hypothesis:
ALTERNATE HYPOTHESIS There is a difference between the efficacy of the PRF, MTA and CH when used as pulpotomy medicaments in mature permanent teeth with irreversible pulpitis NULL HPOTHESIS There is no difference in efficacy of the PRF, MTA and CH when used as pulpotomy medicaments in mature permanent teeth with irreversible pulpitis
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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Group I- Calcium hydroxide (Control)
Group I will receive Calcium hydroxide . Calcium hydroxide is a gold standard medicament for the pulpotomy in deciduous teeth. It has antibacterial effects and widely used to disinfect the root canals.
This group will act as a control
Calcium hydroxide
Calcium hydroxide in the power/liquid form will be used and placed on the exposed pulp
Group II- MTA (Experimental)
Group II will receive MTA (Mineral Trioxide Aggregate). MTA is a calcium silicate based highly biocompatible material that is commonly used for pulpotomies in deciduous teeth along with the regenerative procedures in permanent and deciduous teeth
MTA
Mineral trioxide aggregate will be used as a powder / liquid form and placed over the exposed pulp
Group III- PRF (Experimental)
Group III will receive PRF. PRF is platelet-rich fibrin that is a biocompatible product derived from patient's own blood. It is formed by centrifugation of the blood of the patient. It provides the growth factors and promotes regeneration of the pulp
PRF
PRF will be placed directly over the exposed pulp
Interventions
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Calcium hydroxide
Calcium hydroxide in the power/liquid form will be used and placed on the exposed pulp
MTA
Mineral trioxide aggregate will be used as a powder / liquid form and placed over the exposed pulp
PRF
PRF will be placed directly over the exposed pulp
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Necrotic pulp
* History of swelling, abscess , fistula and/ or sinus tract
* Doubtful restorability as indicated by over all Dental Practicality Index- (DPI) \> 2 (Dawood and Patel 2017) will be excluded
* Periodontal disease
* Uncontrolled bleeding (more that 10 mins.) of pulp after removal of inflamed part.
* No bleeding of pulp at all after access into pulp RADIOGRAPHICALLY (with the use of periapical radiographs) Teeth with
* Internal/ external pathologic root resorption
* Pulp canal obliteration
* Periapical / furcal radiolucency
* Resorbed roots.
* Crestal bone loss Generally patients
* With systemic diseases, bleeding disorders, physical or mental disability, pregnant or nursing.
* On opioid or steroid therapy or anticoagulants and/or on any kind of antibiotics.
* Who have gone through some previous treatment for the same tooth other than filling.
10 Years
70 Years
ALL
Yes
Sponsors
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Ziauddin University
OTHER
Liaquat College of Medicine and Dentistry
OTHER
Responsible Party
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Naheed Najmi
Vice Principal and Registrar
Locations
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Liaquat College of Medicine and Dentistry
Karachi, Sindh, Pakistan
Countries
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Other Identifiers
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EC/13/17
Identifier Type: -
Identifier Source: org_study_id
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