A-prf,Nanochitosan Combined With A-prf Compared to Chitosan for Symptomatic Irreversible Pulpitis of Mature Teeth
NCT ID: NCT06438523
Last Updated: 2024-06-03
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
30 participants
INTERVENTIONAL
2023-09-02
2025-09-02
Brief Summary
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Detailed Description
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Each group will be subjected to tests:
Tooth sensibility via EPT (electrical pulp tester)and thermal test Radiolucency in digital radiograph Pain in NRS(6-12-24-72h)for 1 week
Conditions
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Study Design
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RANDOMIZED
PARALLEL
Intervention 1 : Vital pulp therapy using A-PRF as capping material. Intervention 2 : Vital pulp therapy using A-PRF mixed with Nano-Chitosan as capping material.
Control/Comparator:
Vital pulp therapy using Chitosan as capping material.
TREATMENT
NONE
Study Groups
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Advanced Platelet rich fibrin,A-prf,A-PRF scaffold
A-PRF will be prepared according to Choukroun's technique by drawing whole blood from the median cubital vein into a 10 ml plain plastic test tubes (non-citrated) without the addition of an anticoagulant reagent .
To prevent the blood from coagulating, it will be centrifuged immediately using a table top centrifuge at 1500 rpm for 14 minute.
PULPOTOMY OF MATURE PERMENANT TEETH
Removal of coronal pulp and expose the orifices to apply the materials with aim to preserve vitality of remaining pulp
A-prf mixed with nano chitosan
A-PRF will be prepared according to Choukroun's technique by drawing whole blood from the median cubital vein into a 10 ml plain plastic test tubes (non-citrated) without the addition of an anticoagulant reagent .
To prevent the blood from coagulating, it will be centrifuged immediately using a table top centrifuge at 1500 rpm for 14 minute then mixed with nanochitosan
PULPOTOMY OF MATURE PERMENANT TEETH
Removal of coronal pulp and expose the orifices to apply the materials with aim to preserve vitality of remaining pulp
chitosan
he access cavity will be prepared up to the level of pulp chamber floor using sterile round diamond bur size 1 in high-speed hand piece with coolant.Once the pulp has been reached, a sharp sterile excavator should be used to remove the pulp tissue to the level of the radicular/root canal orifices then chitosan will be applied
PULPOTOMY OF MATURE PERMENANT TEETH
Removal of coronal pulp and expose the orifices to apply the materials with aim to preserve vitality of remaining pulp
Interventions
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PULPOTOMY OF MATURE PERMENANT TEETH
Removal of coronal pulp and expose the orifices to apply the materials with aim to preserve vitality of remaining pulp
Eligibility Criteria
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Inclusion Criteria
* Patients of either gender aged from 15-30.
* Tooth should give positive response to cold test.
* Haemostasias should be achieved after total pulpotomy.
* The tooth is restorable and free from advanced periodontal disease, cracks and splits.
* Patients should be free from any systemic disease that may affect normal healing and predictable outcome.
* Patients who will agree to the consent and will commit to follow-up period.
* Patients with mature root.
* Patients with no internal or external resorption and no periapical lesions.
* Soft tissues around the tooth are normal with no swelling or sinus tract.
Exclusion Criteria
* Haemostasias after 10 minutes can not be controlled after total pulpotomy
* Patients with any systemic disease that may affect normal healing.
* Patients with periapical lesions or infections.
* Pregnant females.
* Patients who could/would not participate in a 6 months follow-up.
* Patients with fistula or swelling
* Patients with necrotic pulp.
* Patients with old age.
15 Years
30 Years
ALL
Yes
Sponsors
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Future University in Egypt
OTHER
Responsible Party
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Mai Sherif
Researcher
Principal Investigators
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wael H Kamel, Prof.
Role: STUDY_DIRECTOR
Future University in Egypt
Hani s sadek, Prof.
Role: PRINCIPAL_INVESTIGATOR
Future University in Egypt
Locations
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Future university
Cairo, Fifth Settlement, Egypt
Countries
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Central Contacts
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Facility Contacts
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Mai Sheriff Abdelwahed, Researcher
Role: primary
Other Identifiers
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29
Identifier Type: -
Identifier Source: org_study_id
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