Effect of NanoChitosan Impregnated Calcium Hydroxide as an Intracanal Medication on Postoperative Pain Intensity and Bacterial Load Reduction
NCT ID: NCT06253247
Last Updated: 2024-02-12
Study Results
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Basic Information
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NOT_YET_RECRUITING
NA
45 participants
INTERVENTIONAL
2024-04-30
2024-06-30
Brief Summary
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Detailed Description
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1. After placement of intracanal medicament at 6, 12, 24 and 48 hours.
2. After root canal obturation at 6, 12, 24 and 48 hours.
Secondary outcome: Bacterial load reduction determined by bacterial counting using agar culture technique after root canal preparation (CFU/ml)
1. Sample 1 (S1): after access preparation and pre-instrumentation.
2. Sample 2 (S2): post-instrumentation.
3. Sample 3 (S3): post-intracanal medicament removal at 7 days.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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Patients with necrotic mandibular premolars will be treated with NanoChitosan impregnated Ca(OH)2
25-45 years old patients with necrotic single rooted mandibular premolars with single canal will be treated with NanoChitosan impregnated Calcium Hydroxide as an intracanal medicament for 7 days
NanoChitosan impregnated Calcium Hydroxide
NanoChitosan impregnated Calcium Hydroxide used as an intracanal medication fro 7 days
Patients with necrotic mandibular premolars will be treated with Calcium Hydroxide
25-45 years old patients with necrotic single rooted mandibular premolars with single canal will be treated with calcium hydroxide as an intracanal medicament for 7 days
NanoChitosan impregnated Calcium Hydroxide
NanoChitosan impregnated Calcium Hydroxide used as an intracanal medication fro 7 days
Interventions
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NanoChitosan impregnated Calcium Hydroxide
NanoChitosan impregnated Calcium Hydroxide used as an intracanal medication fro 7 days
Eligibility Criteria
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Inclusion Criteria
2. Males or females.
3. Healthy patients who are categorized as I or II according to The American Society of Anesthesiologists. (ASA I or II)
4. Patients' accepting to participate in the trial.
5. Patients who can understand the pain scale and can sign the informed consent.
6. Mandibular Single rooted premolars, having single root canal: Diagnosed clinically with pulp necrosis.
7. Positive pain on percussion denoting apical periodontitis.(20)
8. Slight widening in the periodontal membrane space
9. Normal occlusal contact with opposing teeth
Exclusion Criteria
2. If analgesics or antibiotics have been administrated by the patient during the past 24 hours preoperatively.
3. Pregnant women
4. Patients reporting bruxism, clenching, TMJ problems or traumatic occlusion
5. Patients with two or more adjacent teeth requiring endodontic treatment.
6. Teeth that require further procedural steps or multidisciplinary approach.
1. Association with swelling or fistulous tract.
2. Acute periapical abscess.
3. Mobility Grade II or III.
4. Pocket depth more than 5mm.
5. Previous root canal treatment.
6. Non-restorable.
7. Immature root.
8. Radiographic evidence of external or internal root resorption, vertical root fracture, perforation, calcification.
7. Inability to perceive the given instructions.
25 Years
45 Years
ALL
Yes
Sponsors
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Cairo University
OTHER
Responsible Party
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Yasmine Osama ElGhannam
Principal Investigator
Central Contacts
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Other Identifiers
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ICM 101
Identifier Type: -
Identifier Source: org_study_id
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