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Effect of N-acetylcysteine Versus Calcium Hydroxide Used as an Intracanal Medicament on the Intensity of Postoperative Pain, Bacterial Load Reduction and Levels of MMP -9 in Periapical Fluids in Patients With Necrotic Pulp

NCT ID: NCT05666089

Last Updated: 2022-12-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

EARLY_PHASE1

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-02-01

Study Completion Date

2024-03-01

Brief Summary

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To compare the effect of N-acetylcysteine versus calcium hydroxide as intra canal medication on:

* Intensity of postoperative pain.
* Bacterial load reduction.
* levels of MMP -9 in Periapical Fluids.

Detailed Description

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Conditions

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Intracanal Medication N-acetylcystine Calcium Hydroxide Mediators

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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N-acetylcysteine

intracanal medication of NAC paste

Group Type EXPERIMENTAL

N-acetyl cysteine

Intervention Type DRUG

intracanal medication of NAC with concentration 1 gm/ml in the form of a paste

Calcium hydroxide

intracanal medication of Ca(OH)2 paste

Group Type ACTIVE_COMPARATOR

Calcium hydroxide

Intervention Type DRUG

intracanal medication of calcium hydroxide paste (metapaste)

Interventions

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N-acetyl cysteine

intracanal medication of NAC with concentration 1 gm/ml in the form of a paste

Intervention Type DRUG

Calcium hydroxide

intracanal medication of calcium hydroxide paste (metapaste)

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Patients who are free from any physical or mental handicapping condition.
* Males \& Females with

* Mandibular single rooted permanent premolar teeth.
* Absence of spontaneous pain.
* Slight widening in the periodontal membrane space or with periapical radiolucency not exceeding 2\*2 mm radiographically.
* Patients' acceptance to participate in the trial.
* Patients who can understand pain scale and can sign the informed consent (Appendix I)

Exclusion Criteria

1. Medically compromised patients.
2. Pregnant women
3. Patients undergoing previous endodontic treatment or analgesics and/or antibiotics have been administrated by the patient during the past 24 hours preoperatively.
4. Patients reporting bruxism or clenching.
5. Teeth that show association with acute periapical abscess and swelling.
6. Greater than grade I mobility or pocket depth greater than 5mm.
7. Non-restorable teeth or teeth that could not be adequately isolated with a rubber dam
8. Teeth with vital pulp.
9. Immature teeth.
10. Radiographic evidence of external or internal root resorption vertical root fracture, perforation, calcification.
Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Cairo University

OTHER

Sponsor Role lead

Responsible Party

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Safwa Essam Mohammed Ahmed Abd el-glil

Assistant lecturer

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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FACULTY OF DENTISTRY-cairo university

Cairo, , Egypt

Site Status

Countries

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Egypt

Facility Contacts

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Safwa Es. Abd Elglil, MSc. (cairo university)

Role: primary

Other Identifiers

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safwaendo91

Identifier Type: -

Identifier Source: org_study_id