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Evaluation of Antimicrobial Efficacy and Postoperative Pain After Using Silver Nanoparticles and Chitosan Nanoparticles Against Enterococcus Faecalis and Candida Albicans Biofilm

NCT ID: NCT06172023

Last Updated: 2023-12-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

78 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-01-01

Study Completion Date

2023-03-01

Brief Summary

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Silver nanoparticles possess unique physicochemical and biological properties in addition to their antibacterial capabilities. Similarly, zinc oxide nanoparticles have demonstrated antibacterial effects against a wide range of bacteria, including heat and pressure resistant spores. Given these characteristics, it would be valuable to evaluate and compare a new irrigation solution containing nanosilver and nanozinc-oxide particles with sodium hypochlorite. Furthermore, Chitosan Nanoparticles are expected to exhibit enhanced antibacterial activity compared to regular-sized Chitosan due to their ability to penetrate and disrupt microbial cell membranes. Consequently, the current study aims to assess and compare the antibacterial activity of Silver Nanoparticles and Chitosan Nanoparticles, as well as their impact on post-operative pain.

Detailed Description

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Conditions

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Endodontic Disease

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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Silver Nanoparticles Irrigant

Group Type EXPERIMENTAL

Silver Nanoparticles Irrigant

Intervention Type DRUG

Nanosilver irrigant solution

Chitosan Nanoparticle Irrigant

Group Type EXPERIMENTAL

Chitosan Nanoparticles Irrigant

Intervention Type DRUG

Chitosan nanoparticles irrigant solution

2.6% NaOCl and 17% EDTA sol

Group Type ACTIVE_COMPARATOR

Silver Nanoparticles Irrigant

Intervention Type DRUG

Nanosilver irrigant solution

Chitosan Nanoparticles Irrigant

Intervention Type DRUG

Chitosan nanoparticles irrigant solution

Interventions

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Silver Nanoparticles Irrigant

Nanosilver irrigant solution

Intervention Type DRUG

Chitosan Nanoparticles Irrigant

Chitosan nanoparticles irrigant solution

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Medically stable healthy patients (category: American society of anesthesiologists class I).
* The patient ranges in age from 20 to 40.
* No sexual orientation
* Necrotic pulp evaluated by thermal or electrical pulp testing.
* Enough crown structure to provide adequate isolation.
* One root and one canal.
* Patients' desire to engage in this research.
* Patients' comprehension of the visual analogue scale (VAS).
* Patients' ability to sign informed consent.

Exclusion Criteria

* Endodontic treatment for the tooth previously.
* Teeth with poor conditions for using rubber dams.
* Vital pulp tissue was observed throughout the treatment.
* Patients who have a medical condition.
* Teeth with open apices that are immature
* Women who are pregnant or breastfeeding.
* Psychologically disturbed patients.
* Patients having a history of allergy to any of the research drugs were barred from participation.
* A periodontally affected tooth with grade 2 or 3 mobility.
Minimum Eligible Age

20 Years

Maximum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Minia University

OTHER

Sponsor Role lead

Responsible Party

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Ahmed Amr El Wakad

Doctorate candidate at the Faculty of Dentistry, Minia University

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Faculty of Dentistry, Minia University

Minya, , Egypt

Site Status

Countries

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Egypt

Other Identifiers

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(RHDIRB2017122004) (438)

Identifier Type: -

Identifier Source: org_study_id